Abstract

The GCRC is the major clinical research facility for Stanford University School of Medicine. This? proposal is for a five year renewal, for years 45-49 of this research grant. It involves a total of 138? protocols and 147 investigators from 19 university departments. Our goals are to provide an optimal? facility for the conduct of patient oriented research, to translate basic scientific knowledge into a? better understanding and treatment of human diseases, and to train health professionals in clinical? research. Current space in Stanford University Hospital provides an outstanding inpatient and? outpatient GCRC facility, and a premature infant research program utilizes scatter beds in the? adjacent Lucile Packard Children's Hospital. The seven major programs and investigators which? form the core of this proposal are:? (1) A Phase l/ll Study of Intratumoral Injection of CpG7909, a TLR Agonist, Combined with Local? Radiation in Recurrent Low Grade Lymphomas (Ronald Levy).? (2) Human Immune Response to Natural Infections and Vaccines (Cornelia J. Dekker).? (3) Therapeutic Manipulation of the NOS Pathway in Peripheral Arterial Disease (John P. Cooke).? (4) New Therapeutic Approaches for Colorectal Cancers (Branimir I. Sikic).? (5) The Hypothalamic-Pituitary-Adrenal Axis in Psychotic Depression (Alan Schatzberg).? (6) Neuroimaging and Neurodevelopmental Outcome (David Stevenson).? (7) The Aging Kidney after Contralateral Nephrectomy (Bryan D. Myers).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000070-45
Application #
7130008
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Filart, Rosemarie
Project Start
1997-12-01
Project End
2011-11-30
Budget Start
2007-02-15
Budget End
2007-11-30
Support Year
45
Fiscal Year
2007
Total Cost
$4,173,511
Indirect Cost

  Institution

Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Latva-Rasku, Aino; Honka, Miikka-Juhani; Stan?áková, Alena et al. (2018) A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study. Diabetes 67:334-342
Evangelou, Evangelos (see original citation for additional authors) (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet 50:1412-1425
Doherty, Aiden; Smith-Byrne, Karl; Ferreira, Teresa et al. (2018) GWAS identifies 14 loci for device-measured physical activity and sleep duration. Nat Commun 9:5257
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Frayling, Timothy M; Beaumont, Robin N; Jones, Samuel E et al. (2018) A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Rep 23:327-336
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Di Fiore, Juliann M; Martin, Richard J; Li, Hong et al. (2017) Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. J Pediatr 186:49-56.e1
Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
Holmes, Michael V; Pulit, Sara L; Lindgren, Cecilia M (2017) Genetic and epigenetic studies of adiposity and cardiometabolic disease. Genome Med 9:82
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628

Showing the most recent 10 out of 589 publications