We will determine and compare the multiple dose intrapulmonary pharmacokinetics and plasma concentrations of isoniazid, rifampin, and pyrazinamide in HIV-infected and uninfected patients who are being treated for pulmonary tuberculosis. The GCRC is critical to this study. Patients will undergo bronchoscopy and bronchoalveolar lavage, blood draws, and serial observations.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000079-37A1
Application #
6305320
Study Section
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
37
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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