This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the study is to identify a more favorable diet/exercise treatment for insulin resistance, as well as the cellular and metabolic mediators that regulate obesity-related insulin resistance in the elderly. The central hypothesis is that a short-term low-glycemic diet combined with aerobic exercise reduces insulin resistance in older obese men and women. The research design incorporates screening (2 days), pre-program tests (2 days), intervention (7 days) and post-program tests (2 days). Procedures include 7-days of exercise, randomization to an isocaloric low-glycemic diet (~55 U), or normal diet (Control). Both groups will participate in a 7-day supervised aerobic exercise program. Baseline physiological and metabolic testing will include measures of insulin resistance (euglycemic-hyperinsulinemic clamps), substrate oxidation, total body fat (DEXA), intramyocellular lipid content (proton NMR), and serum adiponectin (Western Blotting). Upon treatment completion, all baseline testing will be repeated to determine the study outcome effects. The proposed research will involve the prospective study of 34 older (60-80 years), obese (BMI = 30-40 kg/m2) men and women.
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