Elevations in ambient particulate matter(PM)air pollution have been associated with increases in hospital admissions and emergency department visits for asthma and other respiratory illnesses, and with excess daily mortality. This study seeks to examine the effects of particulate matter on asthmatics by determining to which components of PM asthmatics are most sensitive, and by what mechanism. Baseline serum and nasal lavage levels of proinflammatory mediators, as well as TH1 and TH2 induced cells, will be identified at low PM and high PM exposure. Epidimiologic data on PM will also be collected and correlated to the asthmatic's symptoms.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000096-39
Application #
6412489
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1975-10-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
39
Fiscal Year
2000
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
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