This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objectives Primary Objective To evaluate the safety of escalating doses of 14g2a.zeta chimeric receptor transduced autologous EBV specific cytotoxic T-lymphocytes (EBV-CTL) and 14g2a.zeta transduced autologous peripheral blood T-cells administered to patients with Neuroblastoma who have been lymphodepleted by CD45 monoclonal antibodies (MAbs). Secondary Objectives To determine the differential survival and function of these two infused cell-types in vivo, in particular to determine if chimeric receptor transduced EBV-CTLs survive longer than transduced peripheral-blood T-cells. To determine anti-tumor effects of transduced peripheral blood T-cells and EBV specific CTLs in vivo.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
Schools of Medicine
United States
Zip Code
Utzinger, Linsey M; Gowey, Marissa A; Zeller, Meg et al. (2016) Loss of control eating and eating disorders in adolescents before bariatric surgery. Int J Eat Disord 49:947-952
Lee, B; Diaz, G A; Rhead, W et al. (2016) Glutamine and hyperammonemic crises in patients with urea cycle disorders. Mol Genet Metab 117:27-32
El-Hattab, Ayman W; Emrick, Lisa T; Hsu, Jean W et al. (2016) Impaired nitric oxide production in children with MELAS syndrome and the effect of arginine and citrulline supplementation. Mol Genet Metab 117:407-12
Bansal, N; Hampe, C S; Rodriguez, L et al. (2016) DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes. Diabet Med :
Nishimura, Katherine K; Iwanaga, Kensho; Oh, Sam S et al. (2016) Early-life ozone exposure associated with asthma without sensitization in Latino children. J Allergy Clin Immunol 138:1703-1706.e1
Inge, Thomas H; Courcoulas, Anita P; Jenkins, Todd M et al. (2016) Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. N Engl J Med 374:113-23
Spurney, Christopher F; McCaffrey, Francis M; Cnaan, Avital et al. (2015) Feasibility and Reproducibility of Echocardiographic Measures in Children with Muscular Dystrophies. J Am Soc Echocardiogr 28:999-1008
Pino-Yanes, Maria; Thakur, Neeta; Gignoux, Christopher R et al. (2015) Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol 135:228-35
Zeller, Meg H; Inge, Thomas H; Modi, Avani C et al. (2015) Severe obesity and comorbid condition impact on the weight-related quality of life of the adolescent patient. J Pediatr 166:651-9.e4
Nagamani, Sandesh C S; Diaz, George A; Rhead, William et al. (2015) Self-reported treatment-associated symptoms among patients with urea cycle disorders participating in glycerol phenylbutyrate clinical trials. Mol Genet Metab 116:29-34

Showing the most recent 10 out of 422 publications