This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Extracorporeal membrane oxygenation (ECMO) is an accepted therapy for newborns with life-threatening conditions such as diaphragmatic hernia, pulmonary hypertension of the newborn and severe congenital heart disease. These patients are at risk of compromised cerebral perfusion and/or of developing renal failure during ECMO. The efficacy of tissue perfusion in these patients is estimated by a variety of indirect means tissue lactate content, acidosis, blood gas parameters, etc. The primary purpose of this observational study is to assess bilateral cerebral oxygenation when one cerebral hemisphere is potentially compromised, i.e. unilateral carotid ligation or large venous cannula. Furthermore, we hope to relate oxygen saturation to short and long term neurodevelopmental outcomes and to relate renal oxygen saturation to incidence of ECMO related renal failure. Near-infrared spectroscopy (NIRS) is a non-invasive technique that can be used to compute the oxygen saturation for blood in certain tissues. The regional cerebral oxygen saturation index (rSO2i) represents the weighted average of the oxygen saturation of the arteries, venules, and capillaries in certain regions of the brain. We will use this technology to monitor the cerebral blood oxygen saturation of our patients from birth until they go on ECMO, while they are on ECMO, during any surgical repair of defects (whether on ECMO at the time or not), and while the patients are being weaned from ECMO. NIRS data will also be collected from a control group of ECMO candidate neonates that are not placed on ECMO. After the patients have recovered, are off of mechanical ventilation, and are progressing well, a brain MRI is typically performed prior to discharge. The findings of these MRIs as well as the findings of neurological and neurodevelopmental examinations made at six months and one year of age will be analyzed.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
Schools of Medicine
United States
Zip Code
Lanzieri, T M; Leung, J; Caviness, A C et al. (2017) Long-term outcomes of children with symptomatic congenital cytomegalovirus disease. J Perinatol 37:875-880
El-Hattab, Ayman W; Zarante, Ana Maria; Almannai, Mohammed et al. (2017) Therapies for mitochondrial diseases and current clinical trials. Mol Genet Metab 122:1-9
Jin, Haoxing Douglas; Demmler-Harrison, Gail J; Coats, David K et al. (2017) Long-term Visual and Ocular Sequelae in Patients With Congenital Cytomegalovirus Infection. Pediatr Infect Dis J 36:877-882
Zeller, Meg H; Washington, Gia A; Mitchell, James E et al. (2017) Alcohol use risk in adolescents 2 years after bariatric surgery. Surg Obes Relat Dis 13:85-94
Wattacheril, Julia; Lavine, Joel E; Chalasani, Naga P et al. (2017) Genome-Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys. J Pediatr 190:100-107.e2
Zimmerman, Emily; Lau, Chantal (2017) The Development of the Mother-Infant Mutualistic Screening Scale. J Pediatr Mother Care 2:
Thakur, Neeta; Barcelo, Nicolas E; Borrell, Luisa N et al. (2017) Perceived Discrimination Associated With Asthma and Related Outcomes in Minority Youth: The GALA II and SAGE II Studies. Chest 151:804-812
Jenkins, Todd M; Boyce, Tawny W; Ralph Buncher, C et al. (2017) Accuracy of Self-Reported Weight Among Adolescent and Young Adults Following Bariatric Surgery. Obes Surg 27:1529-1532
Lopez, Adriana S; Lanzieri, Tatiana M; Claussen, Angelika H et al. (2017) Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection. Pediatrics 140:
El-Hattab, Ayman W; Almannai, Mohammed; Scaglia, Fernando (2017) Arginine and citrulline for the treatment of MELAS syndrome. J Inborn Errors Metab Screen 5:

Showing the most recent 10 out of 453 publications