This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This will be a double-blind, placebo-controlled, within-subject, inpatient evaluation of potential interactions between intravenous cocaine and doxazosin. Interested candidates who have used cocaine by the smoked intravenous route in the past two weeks and are not seeking treatment, and are available for the 28 days of confinement as a hospital inpatient in the General Clinical Research Center (GCRC), will receive an explanation of the study purpose and requirement. If interested, the candidates will be allowed to review, inquire about and sign the informed consent. After providing signed informed consent, subjects proceed to the screening assessment phase of the study. If subjects meet all entry criteria, they will be enrolled and randomized into the study. Nontreatment-seeking cocaine dependent volunteers will be randomized to receive placebo (n=10) or doxazosin (n=10). Cardiovascular measures and subjective effects ratings will be assessed following cocaine administration.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
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Baylor College of Medicine
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United States
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Utzinger, Linsey M; Gowey, Marissa A; Zeller, Meg et al. (2016) Loss of control eating and eating disorders in adolescents before bariatric surgery. Int J Eat Disord 49:947-952
Lee, B; Diaz, G A; Rhead, W et al. (2016) Glutamine and hyperammonemic crises in patients with urea cycle disorders. Mol Genet Metab 117:27-32
El-Hattab, Ayman W; Emrick, Lisa T; Hsu, Jean W et al. (2016) Impaired nitric oxide production in children with MELAS syndrome and the effect of arginine and citrulline supplementation. Mol Genet Metab 117:407-12
Bansal, N; Hampe, C S; Rodriguez, L et al. (2016) DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes. Diabet Med :
Nishimura, Katherine K; Iwanaga, Kensho; Oh, Sam S et al. (2016) Early-life ozone exposure associated with asthma without sensitization in Latino children. J Allergy Clin Immunol 138:1703-1706.e1
Inge, Thomas H; Courcoulas, Anita P; Jenkins, Todd M et al. (2016) Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. N Engl J Med 374:113-23
Spurney, Christopher F; McCaffrey, Francis M; Cnaan, Avital et al. (2015) Feasibility and Reproducibility of Echocardiographic Measures in Children with Muscular Dystrophies. J Am Soc Echocardiogr 28:999-1008
Pino-Yanes, Maria; Thakur, Neeta; Gignoux, Christopher R et al. (2015) Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol 135:228-35
Zeller, Meg H; Inge, Thomas H; Modi, Avani C et al. (2015) Severe obesity and comorbid condition impact on the weight-related quality of life of the adolescent patient. J Pediatr 166:651-9.e4
Nagamani, Sandesh C S; Diaz, George A; Rhead, William et al. (2015) Self-reported treatment-associated symptoms among patients with urea cycle disorders participating in glycerol phenylbutyrate clinical trials. Mol Genet Metab 116:29-34

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