Abstract

The purpose of this study is to document the effects of pH on newborn hemoglobin-oxygen affinity. Cord blood of acidotic newborns with acute fetal distress during labor and delivery will be studied to evaluate acute adaptations to intrauterine hypoxia and acidosis. The effects of rapid pH changes from acidosis to alkalosis caused by hyperventilation will also be studied in a group of newborns with persistent pulmonary hypertension.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000210-24
Application #
3926422
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Pressler, J L; Hepworth, J T (1997) Behavior of macrosomic and appropriate-for-gestational-age newborns. J Obstet Gynecol Neonatal Nurs 26:198-205
Faruqi, R M; Poptic, E J; Faruqi, T R et al. (1997) Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Am J Physiol 273:H817-26
Nelson, S; Greene, T; Ernhart, C B (1996) Toxocara canis infection in preschool age children: risk factors and the cognitive development of preschool children. Neurotoxicol Teratol 18:167-74
Coffey, M D; Cole, R A; Colles, S M et al. (1995) In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals. J Clin Invest 96:1866-73
Krew, M A; Kehl, R J; Thomas, A et al. (1994) Relation of amniotic fluid C-peptide levels to neonatal body composition. Obstet Gynecol 84:96-100
Faruqi, R; de la Motte, C; DiCorleto, P E (1994) Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J Clin Invest 94:592-600
Chisolm, G M; Ma, G; Irwin, K C et al. (1994) 7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein. Proc Natl Acad Sci U S A 91:11452-6
Greene, T; Ernhart, C B (1993) Dentine lead and intelligence prior to school entry: a statistical sensitivity analysis. J Clin Epidemiol 46:323-39
Kuhnert, B R; Kuhnert, P M; Lazebnik, N et al. (1993) The relationship between placental cadmium, zinc, and copper. J Am Coll Nutr 12:31-5
Philipson, E H; Rossi, K Q; Isaac, R M et al. (1992) Glucose, insulin, gastric inhibitory polypeptide, and pancreatic polypeptide responses to polycose during pregnancy. Obstet Gynecol 79:592-6

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