This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Microvascular complications of diabetes such as eye, kidney and nerve disease are common in individuals with type 1 and type 2 diabetes, and are a source of significant morbidity and mortality. Microvascular complications of diabetes have been anecdotally reported in cystic fibrosis related diabetes (CFRD), but their prevalence is unknown. 40% of adult CF patients have CFRD, which shared features of both type 1 and type 2 diabetes, but is a distinct clinical entity. Many clinicians are reluctant to add the burden of aggressive diabetes management to the already complex medical regimen of CF patients. It is sometimes stated that they will not live long enough to develop microvascular complications of diabetes. However, longevity in CF has dramatically increased, and many patients now live into their thirties, forties and fifties. As they live longer, it becomes increasingly likely that at least some will develop microvascular complications. A better understanding of this negative outcome would help resolve the question of whether aggressive screening and management of diabetes is necessary in CF. The general aim of this project is to determine the prevalence of diabetic microvascular complications in CFRD in patients with and without fasting hyperglycemia, and to explore whether the presence of these complications is related to diabetes of CF factors. This cross-sectional study will provide pilot data for a longitudinal study of diabetes complications in CFRD.
Showing the most recent 10 out of 724 publications
