This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed work will examine whether smokers of popular cigarette products that are low in nitrosamines have lower body burden of nitrosamines compared to smokers of popular cigarette products that have high levels of nitrosamines after correcting for typical individual smoke intake. The tobacco-specific nitrosamines (TSNAs) are some of the most abundant carcinogenic compounds found in tobacco smoke and thus, warrant the most attention. Because of their abundance in tobacco smoke, many scientists believe that the TSNAs are at least partially responsible for the development of lung adenocarcinoma in smokers. The goal of the study is to measure the effects of smoking cigarettes with very different levels of TSNAs on the levels of biomarkers of TSNAs in people. Since tobacco use is the only significant source of TSNA exposure, it is expected that the differences seen in biomarkers will directly reflect the differences in the tobacco products given variation in how people smoke.
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