EXCEED THE SPACEPROVIDED.The University of Minnesota GCRC is now in its 35th year of continuous operation. Since the lastcompetitive renewal, numerous scientific advances were made in human nutrition, neuropsychology,diabetes, cystic fibrosis, systemic lupus erythematosus, cancer, and other areas that are summarized in theAccomplishments Section of this application. This application describes 106 protocols, which are beingimplemented by 194 investigators from various departments, schools, colleges, and institutes at theUniversity: a growth of 70% since the last renewal. Areas of clinical investigation that will be emphasizedover the next five years include: 1) exercise and strength training for obesity prevention, 2) natural history ofthe development of insulin resistance and cardiovascular risk factors in children and young adults, 3) isletcell transplantation, 4) natural killer (NK) cell mediated anti-tumor immunotherapy as an adjunct to blood andmarrow transplantation and other cancer therapies, 5) development of high field 1H MRS as non-invasivediagnostic tool for breast cancer, 6) cerebral effects of insulin-induced hypoglycemia, and 7) development ofcognition in the newborn infants of mothers with diabetes. To assist these investigators, continued supportfor the Cell Therapy, Molecular Genetics, Gas Chromatography/Mass Spectroscopy, Magnetic Resonance,and Infant and Child Development Core laboratories is requested. In addition, in response to investigatorrequests, we propose to expand the breadth of services available to study body composition and vascularfunction into a new Body Composition and Human
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