The GCRC at Harbor-UCLA Medical Center and the satellite GCRC at Cedars-Sinai Medical Center are applying for continued funding of the GCRCs for 5 years (12/01/2006 to 11/30/2011). The Harbor-UCLA GCRC is requesting support for an inpatient unit (800 days), outpatient facilities (9,000 visits), a perinatal/ pediatrics unit (7,000 hrs). The Cedars GCRC satellite is seeking continued support for an outpatient unit, a complex genotype-phenotype core and a perinatal unit working closely with its Harbor counterpart. The current application contains 93 protocols from Harbor and 95 from Cedars, each with Data Safety Monitoring plans. The GCRCs are requesting support for a new joint Clinical Transcriptional Genomics, Proteomics and Molecular Cytology core with 47 protocols utilizing this proposed core. Reviewed and given an excellent score, this core was not funded in 2004 because of NCRR's budgetary constraints. Similar to the GCRC parent grant, the core's strengths include outstanding qualifications of the investigators-core directors, the capability to provide a training environment, and a substantial number of investigators and protocols from a broad range of disciplines. Our institutions have generously provided major equipment in the past 2 years and provided interim support for personnel to run the proposed core. Our presented proto-cols demonstrate the broad base of our well-funded investigators with diverse research including emerging infections, chronic kidney disease, fibroblasts in autoimmunity, male reproduction, neurotrauma, skeletal dysplasia and inflammatory bowel disease. We support high-volume outpatient studies (SELECT, Nutrition and Kidney Disease), high-intensity inpatient studies (Phase I safety and pharmacokinetics studies, metabolic and multiple sample studies), perinatal research (reproductive toxicology, methamphetamine exposed babies), behavior studies (depression, alcohol dependence), and genetics of common diseases (diabetes, diabetic nephropathy, osteoporosis, atherosclerosis). The GCRCs are the focus of clinical research training in their respective institutions reaching out to junior faculty, fellows, and minority graduate and undergraduate students, and our training activity is ranked """"""""outstanding"""""""" in our last review. The GCRCs are positioned to be part of Centers for Clinical and Translational Sciences in our institutions following the NIH Roadmap to reengineer the clinical research enterprise of academic health centers in the nation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000425-42
Application #
7994747
Study Section
Special Emphasis Panel (ZRR1-CR-5 (01))
Program Officer
Talbot, Bernard
Project Start
1997-02-07
Project End
2011-05-31
Budget Start
2010-12-01
Budget End
2011-05-31
Support Year
42
Fiscal Year
2011
Total Cost
$1
Indirect Cost
Name
La Biomed Research Institute/ Harbor UCLA Medical Center
Department
Type
DUNS #
069926962
City
Torrance
State
CA
Country
United States
Zip Code
90502
Williams, Robert C; Elston, Robert C; Kumar, Pankaj et al. (2016) Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics 17:325
Mian, Zainab; Wei, Janet; Bharadwaj, Meghan et al. (2016) Prior myocardial infarction is associated with coronary endothelial dysfunction in women with signs and symptoms of ischemia and no obstructive coronary artery disease. Int J Cardiol 207:137-9
Orr, Chris; Stratton, Jeannette; Rao, Irram et al. (2016) Quantifying Insulin Therapy Requirements to Preserve Islet Graft Function Following Islet Transplantation. Cell Transplant 25:83-95
Sparks, Jeffrey A; Chang, Shun-Chiao; Deane, Kevin D et al. (2016) Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol 68:1828-38
Vargas, Jose D; Manichaikul, Ani; Wang, Xin-Qun et al. (2016) Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 245:230-6
Shufelt, Chrisandra; Elboudwarej, Omeed; Johnson, B Delia et al. (2016) Carotid artery distensibility and hormone therapy and menopause: the Los Angeles Atherosclerosis Study. Menopause 23:150-7
Torday, John S; Miller Jr, William B (2016) Biologic relativity: Who is the observer and what is observed? Prog Biophys Mol Biol 121:29-34
Shah, Anuja; Bross, Rachelle; Shapiro, Bryan B et al. (2016) Dietary energy requirements in relatively healthy maintenance hemodialysis patients estimated from long-term metabolic studies. Am J Clin Nutr 103:757-65
Weng, Liming; Taylor, Kent D; Chen, Yii-Der Ida et al. (2016) Genetic loci associated with nonobstructive coronary artery disease in Caucasian women. Physiol Genomics 48:12-20
Bakir, May; Wei, Janet; Nelson, Michael D et al. (2016) Cardiac magnetic resonance imaging for myocardial perfusion and diastolic function-reference control values for women. Cardiovasc Diagn Ther 6:78-86

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