Epidemiological and experimental lines of evidence support the concept that dietary fat reduction may prevent breast cancer in postmenopausal patients by reducing circulating levels of estradiol which may in turn reduce breast tumor growth. The primary source of estradiol after menopause is estrone derived from androstenedione by aromization in peripheral tissues. Upper body obesity, a common condition after menopause, is associated with an increased risk for breast cancer as well as increased circulating levels of estradiol resulting from increased aromatization. Reducing caloric intake, reducing fat intake and increasing fiber intake have all been shown to reduce circulating estradiol levels.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000865-26S1
Application #
6118419
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
26
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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