This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bipolar illness and alcoholism have similar underlying neuroendocrine abnormalities, however these similarities have not been well studied. Specifically, this study will assess the presence of hypothalamo-pituitary-adrenal (HPA) axis activation as a predictor of alcohol relapse in bipolar patients by 1)evaluating and comparing, by a combined dexamethasone/corticotropin-releasing hormone (CRH) neuroendocrine challenge, the hypothalamic-pituitary-adrenal axis (HPA) function of bipolar disorder and co-morbid alcohol abuse or dependence (BP/Etoh)to biopolar disorder without alcohol use (BP), 2)evaluating and comparing the relationship between HPA axis activation and neuropsychological-assessment of executive functioning, verbal memory, and working memory in subjects with bipolar disorder and co-morbid alcohol abuse or dependence (BP/Etoh) and subjects with bipolar disorder and no alcohol abuse or dependence (BP), and 3) evaluating under naturalistic conditions, thus representative of current community treatment standards, whether HPA axis activation is predictive of poor outcome (mood or alcohol relapse).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000865-33
Application #
7374825
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
33
Fiscal Year
2006
Total Cost
$1,201
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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