This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Cystic Fibrosis (CF) is a fatal disorder caused by a mutant CF transport receptor (FGTR) gene encoding an apical membrane chloride channel. Curcumin (Cur), a compound in the spice tumeric rescued defective CFTR and improved survival in mice engineered to express CF. Cur is also a potent anti-opidant that has poor bioavailablility. The bioavailability of Cur can be enhanced using piperine (Pip), a constituent of black pepper. Cur/Pip has not previously been studied in CF patients as a potiental therapeutic agent.We will compare safety, Cur plasma pharmacokinetics, anti-oxidant, and CFTR modulatory effects of oral Cur/Pip (685mg/5mg per capsule) in CF patients and healthy volunteers (HV).
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