This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The serine kinase IKKb has been demonstrated to be a downstream mediator of insulin resistance through inhibition of the insulin receptor substrate and activation of inflammation via NF-kB. High doses of salicylates (aspirin) inhibit IKKb in rodents and improve glucose metabolism in type 2 diabetic (T2D) patients. In contrast to aspirin, salsalate is an equipotent inhibitor of NF-kB but not associated with risk of bleeding. The purpose of this study is to determine the effects of salicylates on inflammation targeting the IKKbeta/Nfkappa B pathway, in a population at risk for development of type 2 diabetes and hyperlipidemia. The study population is young, obese, individuals, ages 18-30, and the study design is a double-blinded placebo controlled, to determine the effects of one month of Salsalate on glycemia, insulin and C-peptide production and inflammatory markers.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Beth Israel Deaconess Medical Center
United States
Zip Code
Dai, Weiying; Duan, Wenna; Alfaro, Freddy J et al. (2017) The resting perfusion pattern associates with functional decline in type 2 diabetes. Neurobiol Aging 60:192-202
Brosnahan, Godela; Abebe, Kaleab Z; Rahbari-Oskoui, Frederic F et al. (2017) Effect of statin therapy on the progression of autosomal dominant polycystic kidney disease. A secondary analysis of the HALT PKD trials. Curr Hypertens Rev :
Torres, Vicente E; Abebe, Kaleab Z; Schrier, Robert W et al. (2017) Dietary salt restriction is beneficial to the management of autosomal dominant polycystic kidney disease. Kidney Int 91:493-500
Seidman, Larry J; Shapiro, Daniel I; Stone, William S et al. (2016) Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study. JAMA Psychiatry 73:1239-1248
Simpson, Norah S; Diolombi, Moussa; Scott-Sutherland, Jennifer et al. (2016) Repeating patterns of sleep restriction and recovery: Do we get used to it? Brain Behav Immun 58:142-151
Thermenos, Heidi W; Juelich, Richard J; DiChiara, Samantha R et al. (2016) Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis. Schizophr Res 173:1-12
Heyer, Christina M; Sundsbak, Jamie L; Abebe, Kaleab Z et al. (2016) Predicted Mutation Strength of Nontruncating PKD1 Mutations Aids Genotype-Phenotype Correlations in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol 27:2872-84
Alfaro, Freddy J; Lioutas, Vasileios-Arsenios; Pimentel, Daniela A et al. (2016) Cognitive decline in metabolic syndrome is linked to microstructural white matter abnormalities. J Neurol 263:2505-2514
Hart, Joseph; Novak, Vera; Saunders, Charles et al. (2016) Transcranial Doppler-Based Surrogates for Cerebral Blood Flow: A Statistical Study. PLoS One 11:e0165536
Bashir, Shahid; Vernet, Marine; Najib, Umer et al. (2016) Enhanced motor function and its neurophysiological correlates after navigated low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in stroke. Restor Neurol Neurosci 34:677-89

Showing the most recent 10 out of 638 publications