This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.BACKGROUND: Toxoplasma gondii is a protozoan microbial parasite that infects a wide range of wild and domestic animals and can be transmitted to human beings. Toxoplasma gondii is an important cause of encephalopathy and death in immunocompromised persons. Mice chronically infected with T. gondii exhibit selective increases in CNS dopamine concentrations (Stibbs, 1985). Increases in CNS dopamine are associated with psychosis in humans, and Obsessive Compulsive Disorder (OCD) like ritualistic behavior in rodents (Eilam & Szechtman, 2005). Interestingly, dopamine activity can also be associated with personality traits in humans, particularly 'novelty seeking' (Cloninger, 1998; Hansenne et al., 2002). Additionally, T. gondii infection in humans can be associated with personality changes (Flegr & Hrdy, 1994; Flegr et al., 1996; Flegr & Havlicek, 1999; Flegr et al., 2000; Novotna et al., 2005), including decreased novelty seeking (Flegr et al., 2003; Novotna et al., 2005).RESEARCH PLAN: We propose to test the association between toxoplasmosis gondii exposure and a specific behavioral phenotype, 'hoarding behavior' and low 'novelty seeking.' Because cats and rodents are common host for toxoplasmosis gondii we plan to make the association of lifetime exposure to cats and rats to Toxoplasmosis gondii infection.METHODS: We will examine the relationship between infection to Toxoplasmosis gondii, hoarding behavior, novelty seeking behavior, and lifetime exposure to household cats or laboratory rats, 80 healthcare professionals who do not have baseline Obsessive Compulsive Disorder. Healthcare professionals are not likely to have significant mental or physical comorbidities. Nevertheless, the office setting provides a personal space in which there is little policing of incipient hoarding behavior. Individual office spaces will be blindly rated for level of hoarding. Subjects will be evaluated for novelty seeking behavior, surveyed for lifetime exposure to cats/laboratory rats, and have serum Toxoplasmosis gondii antibodies drawn as an indication of prior exposure to the parasite.CLINICAL

Public Health Relevance

Pathological horading, (i.e., 'syllogamania', sometimes also called the 'Diogenes Syndrome'), is characterized by domestic squalor, loss of insight, and social withdrawal (Clark, Manikur amp; Gray, 1975; Cooney amp; Hamid, 1995). Affected individuals amass huge quantities of apparently useless and unused articles, including both new and old items, newspapers and magazines, used food containers, bedding, and other useless rubbish. In extreme cases, the living conditions of these persons are filthy and neglected on the exterior. Homes may lack utilities. The interior is often filled with rubbish and clutter to the point of being a health hazard to the person. Diogenes cases are often found living in unsanitary conditions. The living environment may contain numerous pets, insect or rodent infestations, and occasionally human and animal excrement, (i.e., an environment that is conducive to the interspecies transmission of T. gondii) (Patronek, 1999). A majority of these persons also suffer from poor health maintenance including malnutrition and anemia. The Diogenes syndrome is an important public health problem. Cooney amp; Hamid (1995) estimate an annual incidence of the Diogenes Syndrome at 5 per 10,000 persons aged over 60 years. This may be an underestimate, as the available studies are restricted persons who are known to health care providers. Social service providers estimate 1,000 active cases in Manhatten alone, (i.e., a prevalence of 4/10,000) (Ron Alford www.theplan.com; personal communication). Diogenes cases may comprise 25% of Bexar County Adult Protective Services; caseload (personal communication). In this pilot study, we propose to test the association between toxoplasmosis gondii exposure and hoarding behavior. If such an association can be demonstrated, there would be important implications. First, it would demonstrate the capacity of CNS parasites to alter human host behavior in the absence of clinical disease. Second, it would demonstrate the potential for a wide variety of currently unexplained behavioral disorders to be the product of parasitic manipulation. Third, it would offer the potential of specific anti-microbial treatments for an important public health problem.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001346-26
Application #
7627526
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
26
Fiscal Year
2007
Total Cost
$4,987
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Unick, Jessica L; Gaussoin, Sarah A; Hill, James O et al. (2017) Objectively Assessed Physical Activity and Weight Loss Maintenance among Individuals Enrolled in a Lifestyle Intervention. Obesity (Silver Spring) 25:1903-1909
Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2017) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc 65:137-145
Chao, Ariana M; Wadden, Thomas A; Gorin, Amy A et al. (2017) Binge Eating and Weight Loss Outcomes in Individuals with Type 2 Diabetes: 4-Year Results from the Look AHEAD Study. Obesity (Silver Spring) 25:1830-1837
Kawaguchi-Suzuki, M; Bril, F; Kalavalapalli, S et al. (2017) Concentration-dependent response to pioglitazone in nonalcoholic steatohepatitis. Aliment Pharmacol Ther 46:56-61
Johnson, Karen C; Bray, George A; Cheskin, Lawrence J et al. (2017) The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial. J Bone Miner Res 32:2278-2287
Lorenzo, Carlos; Festa, Andreas; Hanley, Anthony J et al. (2017) Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion. Diabetes Care 40:375-382
Belalcazar, L Maria; Papandonatos, George D; Erar, Bahar et al. (2016) Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD. Circ Cardiovasc Genet 9:71-8
Lorenzo, C; Hanley, A J; Rewers, M J et al. (2016) Discriminatory value of alanine aminotransferase for diabetes prediction: the Insulin Resistance Atherosclerosis Study. Diabet Med 33:348-55
Fowler, Sharon P G (2016) Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans. Physiol Behav 164:517-523
Look AHEAD Research Group; Gregg, Edward; Jakicic, John et al. (2016) Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol 4:913-921

Showing the most recent 10 out of 596 publications