The objective of this project is to determine whether or not ammonia generated by Helicobacter pylori urease contributes to the formation of nitrate and N-nitroso compounds. A total of 20 patients infected with Helicobacter pylori will be recruited for the study. Study subjects will be given an oral dose of N-urea before and after receiving anti-H. pylori. Triple therapy N is a stable isotope which poses no risk to patients. The concentration of N-nitrate and N-nitrosoproline will be measured in a 24 hour urine specimen on each occasion. A significant decrease of the urinary concentration of these compounds is hypothesized after clearance of the infection.

Project Start
1997-12-01
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
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