This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research study is designed to evaluate the effect of rosuvastatin versus placebo on carotid intima media thickness (IMT) in asymptomatic participants who are at low risk for cardiovascular events. Participants will have an LDL-cholesterol between 130 and 189 mg/dl. The study will assess whether there is a difference over time in the IMT change in participants who are treated for 2 years with rosuvastatin 40 mg versus placebo. If a significant difference is found, then the rosuvastatin subjects will be examined to determine whether there is significant regression in IMT during the treatment period. A central laboratory will perform all lipid measurements. The central laboratory will also perform safety labs (chemistry panels and pregnancy tests). Safety measurements are clinical evaluation, patient monitoring, and laboratory assessment. Compliance will be monitored by tablet count. Participants may receive cholesterol-lowering medication and may receive a reduction in cholesterol and/or direct health benefits from participation in this s
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