The Einstein-Montefiore GCRC has benefited from the augmentation of clinical research nationally as well as? from Institutional investments that have permitted expansion in its scope and innovation. Our per diem GCRC? provides platforms and tools to sustain a diverse portfolio of research spanning diabetes, epilepsy, aging, and? reproductive physiology, to sickle cell anemia, HIV/AIDS, CVD, and cancer. In our current project period, we? successfully implemented 2 state-of-the-art Cores, one a high-field Magnetic Resonance (MR) Research Core,? and the second an Analytic Core Laboratory providing mass spectrometry and other analyses. Our training? efforts have not only yielded new K12 and K23 investigators who use the GCRC for their projects, but have? also integrated the GCRC with the training mission of the College of Medicine. The GAC and the RSA have? collaborated with the IRBs to put data and safety monitoring guidelines into practice, and we have implemented? secure research informatics management. In the aggregate, the GCRC has experienced dramatic outpatient visit? increases in the past two years, and our investigators have been highly productive; thus, the current application? includes 60 projects, -50% more than in our previous application with a total of over $55 million in Federal? research grant support. The Principal Investigator of the GCRC is Dominick Purpura, MD, Dean of the College? of Medicine, and its Program Director is Harry Shamoon, MD, Associate Dean for Clinical Research. Drs.? Ronald Nagel and Sanjeev Gupta will continue as Associate Program Directors. Jullie Pan MD, PhD and Daniel? Stein, MD are directors of the MR and the Analytic Cores, respectively, and Hillel Cohen, DrPH continues as? GCRC Biostatistician. Margaret Arnim, MBA is the Administrative Director. Owing to the success of our? GCRC in supporting clinical investigation, the Institution is completing a second outpatient GCRC facility and? laboratory adjacent to the new Children's Hospital at Montefiore that will increase capacity and provide a? (heretofore unavailable) site for pediatric clinical research. The GCRC is at the focal point of the Institution's? Strategic Plan for clinical and translational research that includes constructing a $200-million Center for Genetic? and Translational Medicine, recruiting clinical investigators, developing innovative research training and career? development, and facilitating new scientific endeavors. Based on our track record, we hope this application? demonstrates that our GCRC merits further investment. In keeping with growth of the Center, we request? support for an expanded leadership including Associate Program Directors for Pediatrics (Frederick Kaskel? MD,PhD), Research Training (Paul Marantz MD,MPH), and Neurology (Shlomo Shinnar MD,PhD), and also? for the additional personnel and resources to enable this much-needed expansion.
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