The Einstein-Montefiore GCRC has benefited from the augmentation of clinical research nationally as well asfrom Institutional investments that have permitted expansion in its scope and innovation. Our per diem GCRCprovides platforms and tools to sustain a diverse portfolio of research spanning diabetes, epilepsy, aging, andreproductive physiology, to sickle cell anemia, HIV/AIDS, CVD, and cancer. In our current project period, wesuccessfully implemented 2 state-of-the-art Cores, one a high-field Magnetic Resonance (MR) Research Core,and the second an Analytic Core Laboratory providing mass spectrometry and other analyses. Our trainingefforts have not only yielded new K12 and K23 investigators who use the GCRC for their projects, but havealso integrated the GCRC with the training mission of the College of Medicine. The GAC and the RSA havecollaborated with the IRBs to put data and safety monitoring guidelines into practice, and we have implementedsecure research informatics management. In the aggregate, the GCRC has experienced dramatic outpatient visitincreases in the past two years, and our investigators have been highly productive; thus, the current applicationincludes 60 projects, -50% more than in our previous application with a total of over $55 million in Federalresearch grant support. The Principal Investigator of the GCRC is Dominick Purpura, MD, Dean of the Collegeof Medicine, and its Program Director is Harry Shamoon, MD, Associate Dean for Clinical Research. Drs.Ronald Nagel and Sanjeev Gupta will continue as Associate Program Directors. Jullie Pan MD, PhD and DanielStein, MD are directors of the MR and the Analytic Cores, respectively, and Hillel Cohen, DrPH continues asGCRC Biostatistician. Margaret Arnim, MBA is the Administrative Director. Owing to the success of ourGCRC in supporting clinical investigation, the Institution is completing a second outpatient GCRC facility andlaboratory adjacent to the new Children's Hospital at Montefiore that will increase capacity and provide a(heretofore unavailable) site for pediatric clinical research. The GCRC is at the focal point of the Institution'sStrategic Plan for clinical and translational research that includes constructing a $200-million Center for Geneticand Translational Medicine, recruiting clinical investigators, developing innovative research training and careerdevelopment, and facilitating new scientific endeavors. Based on our track record, we hope this applicationdemonstrates that our GCRC merits further investment. In keeping with growth of the Center, we requestsupport for an expanded leadership including Associate Program Directors for Pediatrics (Frederick KaskelMD,PhD), Research Training (Paul Marantz MD,MPH), and Neurology (Shlomo Shinnar MD,PhD), and alsofor the additional personnel and resources to enable this much-needed expansion.
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