Abstract

This contract is one part of the pre-clinical portion of the NIAID Antiviral Substances Program. The Program supports five separate awards to investigators who have developed animal models of viral infections which can be used to test the activity of antiviral agents in vivo. Compounds are evaluated for efficacy both therapeutically and prophylactically. Studies of drug toxicity and effects of drug treatment on the immune response to infection are also pursued. Combination chemotherapy studies are encouraged. The currently awarded series of contractors have at their disposal the following models: University of Utah - herpes encephalitis in mouse, neonatal herpes in mouse, genital herpes in the guinea pig; University of Massachusetts - influenza in the mouse; Yale University - cytomegalovirus in the guinea pig; Baylor College of Medicine - respiratory syncytial virus in the cotton rat, and Tulane University - simian varicella and parainfluenza type 3 in the African Green monkey.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI062522-007
Application #
3595215
Study Section
Project Start
1985-12-02
Project End
1990-12-01
Budget Start
1989-10-25
Budget End
1990-12-01
Support Year
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Gilbert, B E; Wyde, P R; Wilson, S Z et al. (1993) SP-303 small-particle aerosol treatment of influenza A virus infection in mice and respiratory syncytial virus infection in cotton rats. Antiviral Res 21:37-45
Gilbert, B E; Wyde, P R; Ambrose, M W et al. (1992) Further studies with short duration ribavirin aerosol for the treatment of influenza virus infection in mice and respiratory syncytial virus infection in cotton rats. Antiviral Res 17:33-42
Gilbert, B E; Wyde, P R; Wilson, S Z et al. (1991) Aerosol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus. Antimicrob Agents Chemother 35:1448-53
Ambrose, M W; Wyde, P R; Ewasyshyn, M et al. (1991) Evaluation of the immunogenicity and protective efficacy of a candidate parainfluenza virus type 3 subunit vaccine in cotton rats. Vaccine 9:505-11
Wyde, P R; Ambrose, M W; Meyer, H L et al. (1990) Evaluation of the toxicity and antiviral activity of carbocyclic 3-deazaadenosine against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats. Antiviral Res 14:215-25
Wyde, P R; Ambrose, M W; Meyer, H L et al. (1990) Toxicity and antiviral activity of LY253963 against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats. Antiviral Res 14:237-47
Wyde, P R; Gilbert, B E; Ambrose, M W (1989) Comparison of the anti-respiratory syncytial virus activity and toxicity of papaverine hydrochloride and pyrazofurin in vitro and in vivo. Antiviral Res 11:15-26
Gilbert, B E; Wyde, P R (1988) Pharmacokinetics of ribavirin aerosol in mice. Antimicrob Agents Chemother 32:117-21
Gruber, W C; Wilson, S Z; Throop, B J et al. (1987) Immunoglobulin administration and ribavirin therapy: efficacy in respiratory syncytial virus infection of the cotton rat. Pediatr Res 21:270-4
Wyde, P R; Wilson, S Z; Petrella, R et al. (1987) Efficacy of high dose-short duration ribavirin aerosol in the treatment of respiratory syncytial virus infected cotton rats and influenza B virus infected mice. Antiviral Res 7:211-20

Showing the most recent 10 out of 11 publications