Project Start
1998-09-30
Project End
2003-09-29
Budget Start
1999-09-28
Budget End
2000-03-31
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Choo, Hyunah; Beadle, James R; Kern, Earl R et al. (2007) Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters. Antimicrob Agents Chemother 51:611-5
Zhou, Shaoman; Zemlicka, Jiri; Kern, Earl R et al. (2007) Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines. Nucleosides Nucleotides Nucleic Acids 26:231-43
Beadle, James R; Wan, William B; Ciesla, Stephanie L et al. (2006) Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. J Med Chem 49:2010-5
Ruiz, Jacqueline C; Aldern, Kathy A; Beadle, James R et al. (2006) Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine. Antivir Chem Chemother 17:89-95
Zhou, Shaoman; Kern, Earl R; Gullen, Elizabeth et al. (2006) 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1. J Med Chem 49:6120-8
Roy, Atanu; Schneller, Stewart W; Keith, Kathy A et al. (2005) The 4',4'-difluoro analog of 5'-noraristeromycin: a new structural prototype for possible antiviral drug development toward orthopoxvirus and cytomegalovirus. Bioorg Med Chem 13:4443-9
Ambrose, Amalraj; Zemlicka, Jiri; Kern, Earl R et al. (2005) Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity. Nucleosides Nucleotides Nucleic Acids 24:1763-74
Wan, William B; Beadle, James R; Hartline, Caroll et al. (2005) Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro. Antimicrob Agents Chemother 49:656-62
Kriesel, John D; Spruance, Spotswood L; Prichard, Mark et al. (2005) Recurrent antiviral-resistant genital herpes in an immunocompetent patient. J Infect Dis 192:156-61
Yan, Zhaohua; Kern, Earl R; Gullen, Elizabeth et al. (2005) Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity. J Med Chem 48:91-9

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