Produce, characterize, and provide monoclonal and monospecific antibodies to the protein oncogene products of avian and mammalian retroviruses. The monoclonal antibodies will be directed against the amino and carboxy terminal ends of the oncogene and the active site. The antigens used will be synthetic peptides which are identical in sequence to the native oncogene products, but considerably smaller in size. This contract will operate under the payback system for cost reimbursement, but total cost recovery is not anticipated.
| Niman, H L (1989) Monoclonal antibodies to oncogene products. Prog Clin Biol Res 288:35-52 |
| Chesa, P G; Rettig, W J; Melamed, M R et al. (1987) Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy. Proc Natl Acad Sci U S A 84:3234-8 |
| Niman, H L (1986) Human oncogene-related proteins in urine during pregnancy and neoplasia. Clin Lab Med 6:181-96 |
| Niman, H L; Thompson, A M; Yu, A et al. (1985) Anti-peptide antibodies detect oncogene-related proteins in urine. Proc Natl Acad Sci U S A 82:7924-8 |
