Abstract

To evaluate the influence of immunosuppression and therapy with whole body irradiation and chemotherapy on the risk of new malignancies following bone marrow transplantation. The association between development of a new cancer, in particular, new solid tumors, and prolonged immune suppression from chronic GVHD and/or high dose radiation will be estimated. Cancer risk among the cohort of patients not exposed to immune suppression (autologous transplants) will be evaluated. Variation in risk by age at transplantation and time after transplantation will be quantified.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP051027-006
Application #
6052398
Study Section
Project Start
1995-09-30
Project End
1999-09-30
Budget Start
1999-03-25
Budget End
1999-09-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Landgren, Ola; Gilbert, Ethel S; Rizzo, J Douglas et al. (2009) Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation. Blood 113:4992-5001
Witherspoon, R P; Deeg, H J; Storer, B et al. (2001) Hematopoietic stem-cell transplantation for treatment-related leukemia or myelodysplasia. J Clin Oncol 19:2134-41
Witherspoon, R P; Deeg, H J (1999) Allogeneic bone marrow transplantation for secondary leukemia or myelodysplasia. Haematologica 84:1085-7