The research objective of this contract is the nearly pharmacologic evaluation of potential anticonvulsant compounds. The Epilepsy Branch, Division of Convulsive, Developmental and Neuromuscular Disorders of the National Institute of Neurological Disorders and Stroke conducts and extensive Antiepileptic Drug Development (ADD) Program aimed at identifying potential new antiepileptic agents to be used in man. As part of its mission the sponsoring division provides at no cost to suppliers of new chemical entities from industry and academia, a program for the early pharmacologic evaluation of potential anticonvulsant compounds. Active compounds are advanced through a series of pharmacodynamic and pharmacokinetics evaluations which define the compound's anticonvulsant activity, neurotoxicity, effect on hepatic microsomal metabolizing enzymes and pharmacodynamic interactions.

Project Start
1994-06-30
Project End
1999-06-29
Budget Start
1995-09-28
Budget End
1996-10-31
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Utah
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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