The goal of this project is to evaluate the chronic toxicity and carcinogenicity of perfluorooctanoic acid (PFOA) in rats exposed in the diet. PFOA is used as a surfactant in foam fire-fighting agents and in the production of non-stick and stain-resistant products and is persistent in the environment. Reports for the 2-Year chronic toxicity and carcinogenicity studies currently being finalized. These studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. The PFOA studies include 2-year exposures in both with and without perinatal exposure, to evaluate the effect of perinatal exposure. Keywords: toxicity, carcinogenicity, perinatal, perfluorooctanoic acid

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
N01ES55541-19-0-3
Application #
8602481
Study Section
Project Start
2005-05-01
Project End
2013-04-30
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$693,888
Indirect Cost
Name
Battelle Centers/Pub Health Research & Evaluatn
Department
Type
DUNS #
007901598
City
Columbus
State
OH
Country
United States
Zip Code
43201