The goal of this project is to evaluate the chronic toxicity and carcinogenicity of 2-hydroxy-4-methoxybenzophenone (HMB), following dietary exposures. HMB is used in sunscreens. 2-Year chronic toxicity and carcinogenicity studies of HMB are in the in life phase. These studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. In the HMB study, rats were exposed perinatally prior to the 2-year study;this study is in the in life phase. Standard studies conducted in mice are in the histopathology/report writing phase. Keywords: toxicity, carcinogenicity, diet, perinatal, 2-hydroxy-4-methoxybenzophenone

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
N01ES55541-19-0-4
Application #
8602482
Study Section
Project Start
2005-05-01
Project End
2013-04-30
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$693,888
Indirect Cost
Name
Battelle Centers/Pub Health Research & Evaluatn
Department
Type
DUNS #
007901598
City
Columbus
State
OH
Country
United States
Zip Code
43201