NINDS developed an electronic Protocol Tracking Management System (PTMS) for Human subject research protocols for the NINDS IRB. PTMS was developed and refined as a collaborative effort between the IRB chair and staff of the IRB, clinical investigators, and NINDS IT staff over about a 2-yr period and went live in 2005. In FY2007, when the CNS IRB was formed, PTMS was explained to 6 institutes. Subsequently, additional IRBs began using PTMS, and as of June 2011, >1200 protocols from PIs in 17 ICs were using PTMS. NINDS made a substantial investment in developing PTMS and is dedicated to sustaining it. In addition to the cost of development, there are ongoing costs associated with upgrades and changes, troubleshooting and quality assurance, hosting servers, adding users and providing support and training to the users and staff of other IRBs. Currently, 2.5 IT contractors support PTMS;user support has largely been provided by the staff of the CNS IRB office. Some ICs beside NINDS have provided some funding which covers the costs of about 1.5 IT contractors. The CNS IRB staff has added an FTE to continue to be able to provide support to users.