In the Principal Research Core (PRC), the Developmental Projects address issues at specific points in our conceptual model (see Projects 1-3 in Figure 1). Project 1 is focused on whether access to and engagement in evidence-based alcohol treatment for primary care patients with alcohol dependence can be increased through the use of a nonspecialty care approach, and consideration of patient preference and modifications to treatment for nonresponders. This model, referred to as Alcohol Care Management, includes telephone- based assessment and monitoring, pharmacotherapy, and psychosocial support. Therefore, Project 1 addresses the links in our conceptual model between identification in primary care, initial engagement, and acute care. Project 2, on the other hand, is focused on increasing engagement and retention in patients who undergo an intake evaluation in a specialty care program. This project will determine whether offering patients who fail to engage in specialty care the choice of several alternative approaches produces higher rates of engagement and continued participation than further efforts to engage them in specialty care only. This project will also test a telephone-based procedure for re-engaging patients who achieved initial engagement in specialty care but subsequently dropped out. Both projects will also examine whether the experimental conditions lead to better short-term alcohol use outcomes, in addition to better engagement and retention. Moreover, both projects now feature sequential randomizations designs, which are recommended by Murphy et al. (2007) for the development of adaptive algorithms. Project 3 is an initial evaluation of the feasibility and utilization of a highly innovative, web-based adaptive continuing care program developed by the Hazelden Foundation, a premier non-profit provider of residential treatment in Minnesota.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Program Projects (P01)
Project #
5P01AA016821-05
Application #
8382197
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$120,290
Indirect Cost
$55,229
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Lu, Xi; Lynch, Kevin G; Oslin, David W et al. (2016) Comparing treatment policies with assistance from the structural nested mean model. Biometrics 72:10-9
Ertefaie, Ashkan; Wu, Tianshuang; Lynch, Kevin G et al. (2016) Identifying a set that contains the best dynamic treatment regimes. Biostatistics 17:135-48
Lu, Xi; Nahum-Shani, Inbal; Kasari, Connie et al. (2016) Comparing dynamic treatment regimes using repeated-measures outcomes: modeling considerations in SMART studies. Stat Med 35:1595-615
McKay, James R; Drapkin, Michelle L; Van Horn, Deborah H A et al. (2015) Effect of patient choice in an adaptive sequential randomization trial of treatment for alcohol and cocaine dependence. J Consult Clin Psychol 83:1021-32
Van Horn, Deborah H A; Drapkin, Michelle; Lynch, Kevin G et al. (2015) Treatment choices and subsequent attendance by substance-dependent patients who disengage from intensive outpatient treatment. Addict Res Theory 23:391-403
Oslin, David W; Lynch, Kevin G; Maisto, Stephen A et al. (2014) A randomized clinical trial of alcohol care management delivered in Department of Veterans Affairs primary care clinics versus specialty addiction treatment. J Gen Intern Med 29:162-8
McKay, James R (2013) Commentary on Magill & Longabaugh (2013): Specifying the active ingredients in evidence-based treatments-setting the bar too high? Addiction 108:882-3; discussion 883-4
Kranzler, Henry R; McKay, James R (2012) Personalized treatment of alcohol dependence. Curr Psychiatry Rep 14:486-93
McKay, James R (2011) Negative mood, craving, and alcohol relapse: can treatment interrupt the process? Curr Psychiatry Rep 13:431-3
McKay, James R; Van Horn, Deborah; Oslin, David W et al. (2011) Extended telephone-based continuing care for alcohol dependence: 24-month outcomes and subgroup analyses. Addiction 106:1760-9

Showing the most recent 10 out of 16 publications