The overall aim of the Administrative Core of the Comprehensive Alcohol Research Center (CARC) is to provide the scientific, administrative, and financial support needed to conduct the best science on the biobehavioral interactions between alcohol and HIV/AIDS and to evaluate interventions to reduce drinking among those with HIV and those at high risk for HIV transmission. The CARC has 9 integrated parts: an Administrative Core (AC), four Research Components (RC), two Scientific Cores (SC), an Education/Dissemination Component (EDC) and a Pilot Projects Component (PPC), The primary aims of the AC are (1)To provide the organizational structure for effective scientific leadership;(2)To provide general administrative, fiscal and logistical management of daily operations, assure the smooth functioning of the scientific work, and maintain sound policies and procedures;(3)To obtain external oversight from a Scientific Advisory Board, seek Board advice for major decisions/ strategic direction and evaluation of pilot projects, and arrange timely presentations to the Board at periodic intervals;(4)To ensure appropriate allocation to and tracking of use of core resources by Research Components and Pilot Projects;(5)To ensure collaboration and communication among CARC and collaborating investigators(6)To coordinate new extramural grant submissions consistent with the Center's mission;(7)To increase local, regional, national and international visibility of this CARC, attract outside scientists to become active participants, and foster new collaborative and interdisciplinary relationships. The significance of the AC is that it will enhance the various research component projects by allowing more comprehensive, ambitious, and innovative alcohol/HIV research projects to be conducted with high cost efficiency and greater integration of methods and measures across both basic science and clinical studies. Further, it will serve as the nexus for integration of alcohol/HIV science across both proposed components and pilot projects, as well as complementary studies, so as to yield new insights into the mechanisms and interactions of alcohol and HIV to inform treatment that will reduce drinking among those with HIV and others at high risk for transmission.

Public Health Relevance

The Administrative Core provides the structure and oversight for a research center focusing on how alcohol use can adversely impact the long-term health of people living with HIV and contribute to transmission of HIV both nationally and internationally. The center also examines how interventions to reduce alcohol use can improve outcomes in people treated for HIV and slow the transmission of HIV, leading to significant benefits to public health.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Program Projects (P01)
Project #
5P01AA019072-04
Application #
8531066
Study Section
Special Emphasis Panel (ZAA1-DD)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$81,680
Indirect Cost
$31,261
Name
Brown University
Department
Type
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Wray, Tyler B; Pantalone, David W; Kahler, Christopher W et al. (2016) The role of discrimination in alcohol-related problems in samples of heavy drinking HIV-negative and positive men who have sex with men (MSM). Drug Alcohol Depend 166:226-34
Li, Ming; Ramratnam, Bharat (2016) Proteomic Characterization of Exosomes from HIV-1-Infected Cells. Methods Mol Biol 1354:311-26
Midoun, Miriam; Shangani, Sylvia; Mbete, Bibi et al. (2016) How intersectional constructions of sexuality, culture, and masculinity shape identities and sexual decision-making among men who have sex with men in coastal Kenya. Cult Health Sex 18:625-38
Cioe, Patricia A; Gamarel, Kristi E; Pantalone, David W et al. (2016) Cigarette Smoking and Antiretroviral Therapy (ART) Adherence in a Sample of Heavy Drinking HIV-Infected Men Who Have Sex with Men (MSM). AIDS Behav :
Monnig, Mollie A; Kahler, Christopher W; Cioe, Patricia A et al. (2016) Alcohol use predicts elevation in inflammatory marker soluble CD14 in men living with HIV. AIDS Care 28:1434-40
Banerjee, Geetanjoli; Edelman, E Jennifer; Barry, Declan T et al. (2016) Non-medical use of prescription opioids is associated with heroin initiation among US veterans: a prospective cohort study. Addiction 111:2021-2031
Woods, Adam J; Porges, Eric C; Bryant, Vaughn E et al. (2016) Current Heavy Alcohol Consumption is Associated with Greater Cognitive Impairment in Older Adults. Alcohol Clin Exp Res 40:2435-2444
Wray, Tyler B; Grin, Benjamin; Dorfman, Leah et al. (2016) Systematic review of interventions to reduce problematic alcohol use in men who have sex with men. Drug Alcohol Rev 35:148-57
Okafor, Chukwuemeka N; Kelso, Natalie E; Bryant, Vaughn et al. (2016) Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons. Psychol Health Med :1-14
Kahler, Christopher W; Liu, Tao; Cioe, Patricia A et al. (2016) Direct and Indirect Effects of Heavy Alcohol Use on Clinical Outcomes in a Longitudinal Study of HIV Patients on ART. AIDS Behav :

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