The Pilot Project Component (PPC) supports interdisciplinary, collaborative research by providing pilot funding for new initiatives or feasibility projects among early career investigators and more senior investigators who are expanding their existing programs of research to incorporate a new focus on alcohol or HIV. The PPC will support 4 Pilot Projects that have already been reviewed and selected for funding, as well as additional future pilot projects to be solicited and funded in years 2-5. Projects tied to the Central Theme ofthe CARC, which emphasizes interrelations among alcohol, HIV, liver function, neurocognitive function, medication adherence, and high-risk sexual behavior, will be given highest priority. The four initial Pilot Projects include: Pilot 1: Barry Lester, Ph.D. "Prenatal Exposure to Antiretrovirai Therapy and Alcohol: Newborn Neurobehavior". This Pilot will examine the relationship between prenatal exposure to varying levels of alcohol and neurobehavioral deficits in infants also prenatally exposed to antiretrovirai therapy. Pilot 2: Tara White, Ph.D. "Imaging Functional Alcohol Effects in HIV". This Pilot will be conducted in a subset of patients recruited from Research Component 2, with functional brain ROIs analyzed with regard to the impact of alcohol and HIV on functional brain responses to an acute dose of alcohol over the biphasic time course of its effects. Pilot 3: Jack Wands, MD, "Molecular Characteristics of Occult HBV Strains from H1V+ Women with Alcohol Abuse". This Pilot aims to provide molecular virologic information on the impact of occult hepatitis B infection and alcohol on the process of progressive severe liver disease in women with chronic HIV infection. Pilot 4: Susan Kiene, Ph.D. "Alcohol and HIV Risk-taking among Fishermen and Commercial Sex Workers in Uganda". This Pilot uses formative research to understand the dynamics and social situations that facilitate alcohol and sexual risk behavior, identify communication methods that effectively reach the target populations and facilitate community participation in the dissemination of health messages.

Public Health Relevance

The Pilot Project Component (PPC) responsible for the solicitation, review, funding, tracking, and evaluation of Pilot Projects for the CARC. The PPC advances the CARC mission to understand biobehavioral interactions between alcohol and HIV and to develop interventions for heavy alcohol use in the context of HIV infection by funding pilot projects consistent with these Center goals.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAA1-DD)
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Brown University
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Kahler, Christopher W; Wray, Tyler B; Pantalone, David W et al. (2015) Daily associations between alcohol use and unprotected anal sex among heavy drinking HIV-positive men who have sex with men. AIDS Behav 19:422-30
MacKillop, James; Celio, Mark A; Mastroleo, Nadine R et al. (2015) Behavioral economic decision making and alcohol-related sexual risk behavior. AIDS Behav 19:450-8
Kahler, Christopher W; Wray, Tyler B; Pantalone, David W et al. (2015) Assessing sexual motives for drinking alcohol among HIV-positive men who have sex with men. Psychol Addict Behav 29:247-53
Zaller, Nickolas; Huang, Wen; He, Huan et al. (2014) Risky alcohol use among migrant women in entertainment venues in China. Alcohol Alcohol 49:321-6
Caldwell, J Z K; Gongvatana, A; Navia, B A et al. (2014) Neural dysregulation during a working memory task in human immunodeficiency virus-seropositive and hepatitis C coinfected individuals. J Neurovirol 20:398-411
Gongvatana, Assawin; Correia, Stephen; Dunsiger, Shira et al. (2014) Plasma cytokine levels are related to brain volumes in HIV-infected individuals. J Neuroimmune Pharmacol 9:740-50
Nunn, Amy; Yolken, Annajane; Cutler, Blayne et al. (2014) Geography should not be destiny: focusing HIV/AIDS implementation research and programs on microepidemics in US neighborhoods. Am J Public Health 104:775-80
Luo, Xi; Zhang, Sheng; Hu, Sien et al. (2013) Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 136:1231-44
Kwei, Karen; Tang, Xiaoli; Lok, Anna S et al. (2013) Impaired virion secretion by hepatitis B virus immune escape mutants and its rescue by wild-type envelope proteins or a second-site mutation. J Virol 87:2352-7
Bryant, Vaughn E; Kahler, Christopher W; Devlin, Kathryn N et al. (2013) The effects of cigarette smoking on learning and memory performance among people living with HIV/AIDS. AIDS Care 25:1308-16

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