The Virology Support Core of this P60 application brings together strengths in translational HIV-1 medical research that will facilitate the clinical and basic science components of this application. Personnel involved in the Core have greater than 10 years of experience in offering supportive services to HIV prevention, natural history and treatment clinical trials with a special focus on women, MSM and substance abuse cohorts that have been heavily impacted by the HIV epidemic. The Core will process and store all biological samples generated by research components 2,3,4. The Core will also provide basic science support for hypothesis driven clinical and basic science studies on the impact of alcohol ingestion on HIV-1-related pathology in several anatomic compartments in primary human tissue and in animal models in support of research component 1 and pilot projects headed by Drs. Wands. The Core will also be actively involved in the mentorship of P60 investigators and trainees by offering didactic lectures on HIV-1 biology. The large number of clinical samples generated both in the United States and Africa will be maintained as a biobank and will be a powerful tool for further studies. The Virology Support Core will provide valuable infrastructure to the proposed alcohol/HIV centered research studies. The Core's activities will allow the creation of a central processing station for all biologic material generated by this P60 and its very existence will facilitate the proposed research. For the past 20 years, a robust HIV-1 clinical care and research program has been extremely active at Brown University and Fenway Health leading to collaborative studies on HIV-1 natural history, antiviral therapy, anatomic viral burden, drug resistance, vaccinology and basic virology. These efforts have received wide support from several granting organizations including NIH, CDC, Gates Foundation and Doris Duke Charitable Fund. Furthermore, societal impacts of HIV-1 disease have been explored vis a vis drug addiction and incarceration. An equally robust program has been operational on optimizing HIV-1 diagnosis and treatment in resource poor areas of Africa and Asia. The P60 mechanism now allows a systematic marshalling of resources and expertise to focus on alcohol and HIV-1 and unites alcohol investigators with HlV-1 centered investigators. This joining of forces is transformative in nature, a powerful indicator of the essential synergy that is the backbone of the P60 application.

Public Health Relevance

Alcohol use may cause deleterious effects on the clinical course of HIV through multiple mechanisms such as worsening neurocognitive and hepatic functioning, negatively impacting medication adherence and allowing higher risk behavior. The Core will facilitate the study of alcohol and HIV by offering services to the assembled investigators including specimen processing, basic assay support and virologic input into study design and data analysis.

National Institute of Health (NIH)
Research Program Projects (P01)
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Special Emphasis Panel (ZAA1)
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Brown University
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Kahler, Christopher W; Wray, Tyler B; Pantalone, David W et al. (2015) Daily associations between alcohol use and unprotected anal sex among heavy drinking HIV-positive men who have sex with men. AIDS Behav 19:422-30
MacKillop, James; Celio, Mark A; Mastroleo, Nadine R et al. (2015) Behavioral economic decision making and alcohol-related sexual risk behavior. AIDS Behav 19:450-8
Kahler, Christopher W; Wray, Tyler B; Pantalone, David W et al. (2015) Assessing sexual motives for drinking alcohol among HIV-positive men who have sex with men. Psychol Addict Behav 29:247-53
Zaller, Nickolas; Huang, Wen; He, Huan et al. (2014) Risky alcohol use among migrant women in entertainment venues in China. Alcohol Alcohol 49:321-6
Caldwell, J Z K; Gongvatana, A; Navia, B A et al. (2014) Neural dysregulation during a working memory task in human immunodeficiency virus-seropositive and hepatitis C coinfected individuals. J Neurovirol 20:398-411
Gongvatana, Assawin; Correia, Stephen; Dunsiger, Shira et al. (2014) Plasma cytokine levels are related to brain volumes in HIV-infected individuals. J Neuroimmune Pharmacol 9:740-50
Nunn, Amy; Yolken, Annajane; Cutler, Blayne et al. (2014) Geography should not be destiny: focusing HIV/AIDS implementation research and programs on microepidemics in US neighborhoods. Am J Public Health 104:775-80
Luo, Xi; Zhang, Sheng; Hu, Sien et al. (2013) Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 136:1231-44
Kwei, Karen; Tang, Xiaoli; Lok, Anna S et al. (2013) Impaired virion secretion by hepatitis B virus immune escape mutants and its rescue by wild-type envelope proteins or a second-site mutation. J Virol 87:2352-7
Bryant, Vaughn E; Kahler, Christopher W; Devlin, Kathryn N et al. (2013) The effects of cigarette smoking on learning and memory performance among people living with HIV/AIDS. AIDS Care 25:1308-16

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