Project 3: Mayfield MicroRNA: targets for medication development in alcoholism. Chronic alcohol abuse produces lasting changes in brain function that are manifested as tolerance, physical dependence, craving, and other behavioral changes. The Mayfield Project will test the overall hypothesis that these changes are due to the co-ordinated regulation of alcohol-responsive genes by small non-coding RNAs. This Project will explore the role of these regulatory RNAs using several innovative approaches to alcohol research, including profiling of all known microRNAs (miRNAs), next generation sequencing of unique small RNAs, prediction and validation of miRNAs, mRNA target interactions, expression patterns of miRNAs which may act in combination to regulate mRNA expression and delivery of selected alcohol-related miRNAs to brain.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Program Projects (P01)
Project #
1P01AA020683-01
Application #
8201654
Study Section
Special Emphasis Panel (ZAA1-GG (21))
Project Start
Project End
Budget Start
2012-05-04
Budget End
2012-11-30
Support Year
1
Fiscal Year
2012
Total Cost
$160,128
Indirect Cost
$47,628
Name
University of Texas Austin
Department
Type
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
Scott, Luisa L; Iyer, Sangeetha; Philpo, Ashley E et al. (2018) A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo. J Pharmacol Exp Ther 367:282-290
Most, Dana; Salem, Nihal A; Tiwari, Gayatri R et al. (2018) Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice. Addict Biol :
McCarthy, Gizelle M; Warden, Anna S; Bridges, Courtney R et al. (2018) Chronic ethanol consumption: role of TLR3/TRIF-dependent signaling. Addict Biol 23:889-903
Ferguson, Laura B; Zhang, Lingling; Kircher, Daniel et al. (2018) Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach. Mol Neurobiol :
Mayfield, R Dayne (2017) Emerging roles for ncRNAs in alcohol use disorders. Alcohol 60:31-39
Scott, L L; Brecht, E J; Philpo, A et al. (2017) A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus. Sci Rep 7:42433
Tulisiak, Christopher T; Harris, R Adron; Ponomarev, Igor (2017) DNA modifications in models of alcohol use disorders. Alcohol 60:19-30
Harris, R Adron; Bajo, Michal; Bell, Richard L et al. (2017) Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci 37:1139-1155
Cornelison, Garrett L; Daszkowski, Anna W; Pflanz, Natasha C et al. (2017) Interactions between Zinc and Allosteric Modulators of the Glycine Receptor. J Pharmacol Exp Ther 361:1-8
Ponomarev, Igor; Stelly, Claire E; Morikawa, Hitoshi et al. (2017) Mechanistic insights into epigenetic modulation of ethanol consumption. Alcohol 60:95-101

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