Core B will provide mouse model resources, including extensive breeding, colony management and record keeping, intensive monitoring of mice on experimental and lifespan studies, and physiological and pathological assessment. The need for an animal core is paramount in that all projects use mice in a focused manner. Consolidation of animal resources focused on maximizing efficiency and minimizing costs is essential to the success of this program project. The Mouse Core is central to the programmatic efforts of the investigators.
Specific aim 1 is designed to maintain mouse lines relevant for the program project and generate stock mice for experimental procedures for research projects.
Specific aim 2 will provide the resources to conduct physiological and pathological studies in mouse lines relevant to specific research project aims and objectives. These will include a special focus on the physiological and pathological assessment of cardiovascular, skeletal muscle, behavioral and cancer phenotypes.

Public Health Relevance

The need for an animal core is paramount in that all 4 projects propose to use mice. Consolidation of animal resources focused on maximizing efficiency and minimizing costs is essential to the success of this program project. The Animal Core is central to the programmatic efforts of the investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG001751-29
Application #
8378131
Study Section
Special Emphasis Panel (ZAG1-ZIJ-6)
Project Start
Project End
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
29
Fiscal Year
2012
Total Cost
$303,495
Indirect Cost
$106,846
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Campbell, Matthew D; Marcinek, David J (2016) Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods. Biochim Biophys Acta 1862:716-24
Loeb, Lawrence A (2016) Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences. Cancer Res 76:2057-9
Treuting, P M; Snyder, J M; Ikeno, Y et al. (2016) The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents. Vet Pathol 53:244-9
Liu, Sophia Z; Marcinek, David J (2016) Skeletal muscle bioenergetics in aging and heart failure. Heart Fail Rev :
Ahn, Eun Hyun; Lee, Seung Hyuk; Kim, Joon Yup et al. (2016) Decreased Mitochondrial Mutagenesis during Transformation of Human Breast Stem Cells into Tumorigenic Cells. Cancer Res 76:4569-78
Kruse, Shane E; Karunadharma, Pabalu P; Basisty, Nathan et al. (2016) Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell 15:89-99
Chiao, Ying Ann; Kolwicz, Stephen C; Basisty, Nathan et al. (2016) Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts. Aging (Albany NY) 8:314-27
Ahn, Eun Hyun; Hirohata, Kensen; Kohrn, Brendan F et al. (2015) Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing. PLoS One 10:e0136216
Birk, Alexander V; Chao, Wesley M; Liu, Shaoyi et al. (2015) Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia. Biochim Biophys Acta 1847:1075-84
Quarles, Ellen K; Dai, Dao-Fu; Tocchi, Autumn et al. (2015) Quality control systems in cardiac aging. Ageing Res Rev 23:101-15

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