The Administrative Core performs all administrative, accounting and clerical work related to the Program. Production of manuscripts and program reports, preparing financial reports , reviewing expenditures, monitoring budgets and coordinating appropriations. An executive committee composed of the senior investigators and ex-officio members is described in the Administratiive Core. We will perform annual reviews at which all of the work of the previous year is reviewed and discussed and critiques are prepared by outside reviewers. In addition, Dr. Prusiner will meet at least once per month with each of the Project Directors. A well-organized and efficient Adminitrative Core is vital for to Program described in this application.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-2)
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University of California San Francisco
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Wan, William; Stubbs, Gerald (2014) Heterogeneous seeding of HET-s(218-289) and the mutability of prion structures. Prion 8:
Silber, B Michael; Gever, Joel R; Rao, Satish et al. (2014) Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorg Med Chem 22:1960-72
Stöhr, Jan; Condello, Carlo; Watts, Joel C et al. (2014) Distinct synthetic A? prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci U S A 111:10329-34
Watts, Joel C; Giles, Kurt; Patel, Smita et al. (2014) Evidence that bank vole PrP is a universal acceptor for prions. PLoS Pathog 10:e1003990
Watts, Joel C; Prusiner, Stanley B (2014) Mouse models for studying the formation and propagation of prions. J Biol Chem 289:19841-9
Watts, Joel C; Condello, Carlo; Stöhr, Jan et al. (2014) Serial propagation of distinct strains of A? prions from Alzheimer's disease patients. Proc Natl Acad Sci U S A 111:10323-8
Wan, William; Stubbs, Gerald (2014) Fiber diffraction of the prion-forming domain HET-s(218-289) shows dehydration-induced deformation of a complex amyloid structure. Biochemistry 53:2366-70
Wan, William; Stubbs, Gerald (2014) Fungal prion HET-s as a model for structural complexity and self-propagation in prions. Proc Natl Acad Sci U S A 111:5201-6
Kurouski, Dmitry; Lu, Xuefang; Popova, Ludmila et al. (2014) Is supramolecular filament chirality the underlying cause of major morphology differences in amyloid fibrils? J Am Chem Soc 136:2302-12
Li, Zhe; Gever, Joel; Rao, Satish et al. (2013) Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds. ACS Med Chem Lett 4:397-401

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