The Clinical Core provides the Projects with data from epidemiological, neuropsychological, medical and physical measures. The Core is responsible for obtaining informed consent for participation in the EAS and for participation in the brain donation program. The Core's primary function is characterization of EAS subjects through baseline and annual follow-up clinical and neuropsychological evaluations, including the assignment of cognitive and dementia diagnoses. All subjects undergo an in-person Clinical Core evaluation at baseline and subsequent 12-month intervals. The Core also conducts Consensus Case Conferences to assign clinical cognitive outcomes for each subject at each Wave (annual evaluation). Clinical outcomes assigned include: 1) Diagnosis of DSM-IV 'Dementia'versus 'No Dementia';2) for subjects with dementia, subtypes are diagnoses using standard criteria;and 3) Intermediate States of Cognitive Impairment (amnestic Mild Cognitive Impairment, non-amnestic Mild Cognitive Impairment). The Clinical Core cooperates with the Administrative Core to collect follow-up medical and neuropsychological information for study subjects no longer able to return for in-person evaluations. Data from the Clinical Core are used to determine subject eligibility for participation in Projects. Finally, the Clinical Core collects, distributes, and banks biological specimens for current and future assays.
The Clinical Core collects epidemiological, neuropsychological and neurological data to service research projects. These data are used to assign diagnoses, to develop other outcome variables, correlate with neuropathologic findings and experimental neuropsychological procedures and locomotor outcomes. The Clinical Core ascertains all the confounders and effect modifiers of dementia risk.
|Hill, Nikki L; Mogle, Jacqueline (2018) Alzheimer's disease risk factors as mediators of subjective memory impairment and objective memory decline: protocol for a construct-level replication analysis. BMC Geriatr 18:260|
|Eurelings, Lisa Sm; van Dalen, Jan Willem; Ter Riet, Gerben et al. (2018) Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data. Clin Epidemiol 10:363-379|
|Scott, Stacey B; Sliwinski, Martin J; Zawadzki, Matthew et al. (2018) A Coordinated Analysis of Variance in Affect in Daily Life. Assessment :1073191118799460|
|Blumen, Helena M; Brown, Lucy L; Habeck, Christian et al. (2018) Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study. Brain Imaging Behav :|
|Kidana, Kiwami; Tatebe, Takuya; Ito, Kaori et al. (2018) Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO Mol Med 10:|
|Sanchez-Contreras, Monica Y; Kouri, Naomi; Cook, Casey N et al. (2018) Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci. Mol Neurodegener 13:37|
|Kasanuki, Koji; Ross, Owen A; DeTure, Michael A et al. (2018) Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs. Mov Disord 33:333-334|
|Ogaki, Kotaro; Martens, Yuka A; Heckman, Michael G et al. (2018) Multiple system atrophy and apolipoprotein E. Mov Disord 33:647-650|
|Hyun, Jinshil; Sliwinski, Martin J; Almeida, David M et al. (2018) The moderating effects of aging and cognitive abilities on the association between work stress and negative affect. Aging Ment Health 22:611-618|
|Fleysher, Roman; Lipton, Michael L; Noskin, Olga et al. (2018) White matter structural integrity and transcranial Doppler blood flow pulsatility in normal aging. Magn Reson Imaging 47:97-102|
Showing the most recent 10 out of 319 publications