The Statistical Core serves two functions that are essential for the success of the Einstein Aging Study (EAS). First, the Statistical Core maximizes data quality by implementing a database system that integrates and manages the data collected from the Administrative, Clinical, Neuropathology and Neuroimaging Cores, and from each of the four projects. The Statistical Core assumes responsibility for quality control procedures and for merging data across Projects and Cores. Second, the Statistical Core provides collaborative and consultative support to Project investigators on matters of study design, data analyses and interpretation of results. The Statistical Core is responsible for developing, implementing and interpreting statistical methods appropriate to specific research questions and hypotheses, and it collaborates regulariy with Project investigators on scientific manuscripts.
Specific Aims of the Statistical Core are:
Aim 1. To implement and oversee data procedures to facilitate the seamless exchange of data and ideas among Cores and Projects, and to facilitate data transfer for collaborations with investigators outside the EAS.
Aim 2. To provide a general analytic framework for hypothesis testing, model building and integration of results and analyses across measurement constructs (e.g., exposures, mechanisms, outcomes), and to collaborate with investigators regarding the framing and testing of hypotheses and to provide expertise in the design and conduct of analyses.
Aim 3. To develop new statistical methodology and to apply existing methodology in innovative ways to help to fulfill the other aims of this Core and the Projects and to further aging research in general.

Public Health Relevance

The Statistical Core's contribution to the Program Project is essential and significant because it is needed (1) To ensure a high quality of data;(2) To ensure proper analysis of data for hypothesis testing and hypothesis generation;and (3) To ensure that the data collected in each project and core are optimally utilized for both project specific and cross-project analyses.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-1)
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Albert Einstein College of Medicine
United States
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Hall, Charles B; Lipton, Richard B; Katz, Mindy J et al. (2015) Correcting Bias Caused by Missing Data in the Estimate of the Effect of Apolipoprotein ?4 on Cognitive Decline. J Int Neuropsychol Soc 21:85-90
Ezzati, Ali; Zimmerman, Molly E; Katz, Mindy J et al. (2014) Hippocampal subfields differentially correlate with chronic pain in older adults. Brain Res 1573:54-62
Davidai, G; Cotton, D; Gorelick, P et al. (2014) Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. Eur J Neurol 21:1311-7
Aurora, S K; Dodick, D W; Diener, H-C et al. (2014) OnabotulinumtoxinA for chronic migraine: efficacy, safety, and tolerability in patients who received all five treatment cycles in the PREEMPT clinical program. Acta Neurol Scand 129:61-70
Ayers, Emmeline I; Tow, Amanda C; Holtzer, Roee et al. (2014) Walking while talking and falls in aging. Gerontology 60:108-13
Blumen, Helena M; Holtzer, Roee; Brown, Lucy L et al. (2014) Behavioral and neural correlates of imagined walking and walking-while-talking in the elderly. Hum Brain Mapp 35:4090-104
Lipton, Richard B; Buse, Dawn C; Hall, Charles B et al. (2014) Reduction in perceived stress as a migraine trigger: testing the "let-down headache" hypothesis. Neurology 82:1395-401
Lipton, Richard B; Serrano, Daniel; Pavlovic, Jelena M et al. (2014) Improving the classification of migraine subtypes: an empirical approach based on factor mixture models in the American Migraine Prevalence and Prevention (AMPP) Study. Headache 54:830-49
Kouri, Naomi; Carlomagno, Yari; Baker, Matthew et al. (2014) Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration. Acta Neuropathol 127:271-82
Murray, Melissa E; Cannon, Ashley; Graff-Radford, Neill R et al. (2014) Differential clinicopathologic and genetic features of late-onset amnestic dementias. Acta Neuropathol 128:411-21

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