Converging lines of evidence from anatomical, clinical, and experimental studies from Einstein Aging Study and other aging cohorts indicate that the locomotor function is impaired early in the course of cognitive decline, and may be a marker for cognitive and non-cognitive outcomes in older adults. We conceptualize locomotor function in older adults as those performed under simple and complex conditions. Simple locomotor functions are defined as walking at normal pace without any distractions, and are measured using clinical rating scales and quantitative methods. Complex locomotor functions are those required to maintain locomotion in presence of cognitive (walking while talking) and environmental (spatial navigation) challenges. The complex condition may more closely approximate 'real world'abilities, and by stressing locomotor function in high-risk adults reveal early stages of cognitive and locomotor decline. Our overall hypothesis is that cognition and locomotion functions are vulnerable to common disease processes that result in impairments, which in turn will help identify individuals at high risk for cognitive and motor decline. While multiple pathological pathways lead to cognitive and locomotor decline, in this Einstein Aging Study program project 3 (Locomotor Function In Cognitive Aging And Cognitive Decline) we will focus on vascular status and function as well as hippocampal function and morphology that are vulnerable to processes such as stress and pain. Building on our studies during our current funding period that have established locomotion-cognition associations in the Einstein Aging Study cohort, we propose a comprehensive study of locomotion and cognition in almost 1300 participants (active and to be recruited) over a five-year period with the following aims. We will establish the role of subclinical vascular pathology and brain substrates assessed using multiple neuroimaging modalities on locomotion (Aim 1). We will examine the influence of hippocampal morphology and function, measured using neuroimaging and memory functions, on locomotion (Aim 2). Explore the temporal relationships of locomotion and cognition in aging (Aim 3). Finally, we will define the role of simple and complex locomotion tasks in predicting cognitive transitions and falls in older adults in community and institutional settings (Aim 4).
Project 3 aims to determine the role of locomotor function in cognitive aging and cognitive decline. Establishing the role of simple and complex locomotor deficits in different stages of cognitive decline will have a major impact on enhancing strategies of very early detection of cognitive decline, with important implications for treatment of related outcomes.
|Galioto, Rachel; O'Leary, Kevin C; Thomas, J Graham et al. (2017) Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity. J Headache Pain 18:41|
|Miller, Jeremy A; Guillozet-Bongaarts, Angela; Gibbons, Laura E et al. (2017) Neuropathological and transcriptomic characteristics of the aged brain. Elife 6:|
|Ezzati, Ali; Wang, Cuiling; Lipton, Richard B et al. (2017) Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology. J Am Geriatr Soc 65:1836-1841|
|Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384|
|Eslami, Vahid; Katz, Mindy J; White, Robert S et al. (2017) Pain Intensity and Pain Interference in Older Adults: Role of Gender, Obesity and High-Sensitivity C-Reactive Protein. Gerontology 63:3-12|
|Ezzati, Ali; Rundek, Tatjana; Verghese, Joe et al. (2017) Transcranial Doppler and Lower Extremity Function in Older Adults: Einstein Aging Study. J Am Geriatr Soc 65:2659-2664|
|Grober, Ellen; Wakefield, Dorothy; Ehrlich, Amy R et al. (2017) Identifying memory impairment and early dementia in primary care. Alzheimers Dement (Amst) 6:188-195|
|Sundermann, Erin E; Katz, Mindy J; Lipton, Richard B (2017) Sex Differences in the Relationship between Depressive Symptoms and Risk of Amnestic Mild Cognitive Impairment. Am J Geriatr Psychiatry 25:13-22|
|Scott, Stacey B; Ram, Nilam; Smyth, Joshua M et al. (2017) Age differences in negative emotional responses to daily stressors depend on time since event. Dev Psychol 53:177-190|
|Scemes, Eliana; Zammit, Andrea R; Katz, Mindy J et al. (2017) Associations of cognitive function and pain in older adults. Int J Geriatr Psychiatry 32:118-120|
Showing the most recent 10 out of 291 publications