The Biostatistical and Analytic Core (BAC) will provide advanced statistical and analytic support for all experimental projects within the Program Project Grant (PPG) and will be instrumental for achieving the overall aim of quantifying the relative contributions of sleep loss and circadian disruption on metabolism in healthy older people. To achieve this overall aim, the BAC will analyze data collected in the proposed PPG, as well as data across studies from the proposed, current, and previous PPGs and other studies conducted in the same facilities by PPG investigators. The integrative power of the PPG will therefore enable the BAC to extend the work of the individual experimental Projects by using data from multiple projects. This integration will allow more powerful and detailed statistical analyses, as well as cross-experiment analyses and comparisons that will enable stronger conclusions to be made about the effects of sleep loss and circadian disruption on physiology, metabolism and autonomic function in humans and rodents. The BAC specific aims are: (SA1) To conduct the primary and secondary statistical analyses for each of the individual projects within the PPG using state-of-the-art statistical and analytic methods for evaluating the specific aims of each individual project;(SA2 and SAS) To quantify the effects of sleep loss and circadian disruption, their interaction, and recovery from these exposures on various metrics of metabolism (SA2) and autonomic function (SAS) by using longitudinal analyses and by analyzing and comparing data across different experimental protocols. Analytic and statistical methods - along with the bio-mathematical models developed by the Analytic Cores within previous PPGs - have been used to design and to analyze most experiments in the Brigham and Women's Hospital (BWH) Division of Sleep Medicine (DSM). New methods are required because of the longitudinal, correlated, and frequently non-normal distributions of the data collected. Appropriate statistical and modeling techniques determine whether an intervention has a significant effect, and to enable extraction of additional information from previously collected data. Therefore, the BAC will support and greatly extend the results of the PPG experimental work.
The BAC will provide biostatistical support to all projects, will apply analytic and statistical techniques to the complex, longitudinal, and frequently non-normally distributed and correlated data sets. By integrating data from multiple experiments, the BAC will quantify the relative contributions of sleep loss and circadian disruption on metabolism and autonomic function in older people and rodents.
|Leise, Tanya L; Goldberg, Ariella; Michael, John et al. (2018) Recurring circadian disruption alters circadian clock sensitivity to resetting. Eur J Neurosci :|
|Zitting, Kirsi-Marja; Münch, Mirjam Y; Cain, Sean W et al. (2018) Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults. Sci Rep 8:11052|
|McHill, Andrew W; Hull, Joseph T; McMullan, Ciaran J et al. (2018) Chronic Insufficient Sleep Has a Limited Impact on Circadian Rhythmicity of Subjective Hunger and Awakening Fasted Metabolic Hormones. Front Endocrinol (Lausanne) 9:319|
|Li, Peng; Yu, Lei; Lim, Andrew S P et al. (2018) Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement 14:1114-1125|
|Todd, William D; Fenselau, Henning; Wang, Joshua L et al. (2018) A hypothalamic circuit for the circadian control of aggression. Nat Neurosci 21:717-724|
|Naganuma, Fumito; Bandaru, Sathyajit S; Absi, Gianna et al. (2018) Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy. Neurobiol Dis 120:12-20|
|Asgari-Targhi, Ameneh; Klerman, Elizabeth B (2018) Mathematical modeling of circadian rhythms. Wiley Interdiscip Rev Syst Biol Med :e1439|
|Kroeger, Daniel; Absi, Gianna; Gagliardi, Celia et al. (2018) Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice. Nat Commun 9:4129|
|Gottlieb, Daniel J; Ellenbogen, Jeffrey M; Bianchi, Matt T et al. (2018) Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study. BMC Med 16:44|
|Biello, Stephany M; Bonsall, David R; Atkinson, Lynsey A et al. (2018) Alterations in glutamatergic signaling contribute to the decline of circadian photoentrainment in aged mice. Neurobiol Aging 66:75-84|
Showing the most recent 10 out of 208 publications