Two related human research projects are proposed as part of this program project (PPG) that require quantitative assessment of sleep and wakefulness. Polysomnography (PSG) is the gold standard for such assessments. We have therefore developed a plan for the continuation of a PSG Core as part of this Program, in support of these projects, to ensure the accurate and efficient acquisition, analysis and interpretation of PSG derived measures of sleep and wakefulness. Over the years, PSG methodology has undergone dramatic changes that allow for the collection and analysis of large digitized data sets. Moreover, these developments have resulted in a high degree of sophistication of PSG hardware and software that require a team of specialists who operate and maintain these tools. The general objective of the proposed PSG Core is to provide a knowledge base and an integrated infrastructure to maintain high quality standards in PSG in support of Projects 1 and 2 as well as the Biostatistical and Analytic Core within the program. Specifically, the objectives of the PSG Core will include the following activities: 1. Acquisition and maintenance of PSG equipment and supplies 2. Training of technical research staff at the BWH Center for Clinical Investigation (CCI) in equipment use and instrumentation of research subjects for PSG 3. Assisting in PSG quality assurance at the CCI, and providing technical advice to staff and investigators 4. Archival of digitized PSG data 5. Vigilance state scoring of PSG recordings, and scoring of slow eye movements as a measure of attention failures in wake recordings 6. Quantitative analysis of the sleep EEG with Fast Fourier Transform-routine based spectral analysis in order to obtain measures of homeostatic sleep pressure and circadian sleep drive.
The Polysomnography Core will enable and coordinate the utilization of specialized personnel, facilities, and technology across Projects 1 and 2, and will therefore be central to the success of the overall PPG. The Core will at the same time ensure standardized qualify control criteria for the acquisition, analysis and interpretation of the polysomnography data of the human research projects.
|Lin, Chen; Chang, Yi-Chung; Cheng, Ya-Chen et al. (2016) Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System. Sci Rep 6:31950|
|Yeh, Chien-Hung; Lo, Men-Tzung; Hu, Kun (2016) Spurious cross-frequency amplitude-amplitude coupling in nonstationary, nonlinear signals. Physica A 454:143-150|
|Vetrivelan, Ramalingam; Kong, Dong; Ferrari, Loris L et al. (2016) Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience 336:102-113|
|Markt, Sarah C; Flynn-Evans, Erin E; Valdimarsdottir, Unnur A et al. (2016) Sleep Duration and Disruption and Prostate Cancer Risk: a 23-Year Prospective Study. Cancer Epidemiol Biomarkers Prev 25:302-8|
|Morris, Christopher J; Purvis, Taylor E; Hu, Kun et al. (2016) Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A 113:E1402-11|
|Klerman, Elizabeth B; Beckett, Scott A; Landrigan, Christopher P (2016) Applying mathematical models to predict resident physician performance and alertness on traditional and novel work schedules. BMC Med Educ 16:239|
|Lo, Men-Tzung; Chiang, Wei-Yin; Hsieh, Wan-Hsin et al. (2016) Interactive Effects of Dorsomedial Hypothalamic Nucleus and Time-Restricted Feeding on Fractal Motor Activity Regulation. Front Physiol 7:174|
|Shaw, Natalie D; McHill, Andrew W; Schiavon, Michele et al. (2016) Effect of Slow Wave Sleep Disruption on Metabolic Parameters in Adolescents. Sleep 39:1591-9|
|Duffy, Jeanne F; Scheuermaier, Karine; Loughlin, Kevin R (2016) Age-Related Sleep Disruption and Reduction in the Circadian Rhythm of Urine Output: Contribution to Nocturia? Curr Aging Sci 9:34-43|
|Bermudez, Eduardo B; Klerman, Elizabeth B; Czeisler, Charles A et al. (2016) Prediction of Vigilant Attention and Cognitive Performance Using Self-Reported Alertness, Circadian Phase, Hours since Awakening, and Accumulated Sleep Loss. PLoS One 11:e0151770|
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