Two related human research projects are proposed as part of this program project (PPG) that require quantitative assessment of sleep and wakefulness. Polysomnography (PSG) is the gold standard for such assessments. We have therefore developed a plan for the continuation of a PSG Core as part of this Program, in support of these projects, to ensure the accurate and efficient acquisition, analysis and interpretation of PSG derived measures of sleep and wakefulness. Over the years, PSG methodology has undergone dramatic changes that allow for the collection and analysis of large digitized data sets. Moreover, these developments have resulted in a high degree of sophistication of PSG hardware and software that require a team of specialists who operate and maintain these tools. The general objective of the proposed PSG Core is to provide a knowledge base and an integrated infrastructure to maintain high quality standards in PSG in support of Projects 1 and 2 as well as the Biostatistical and Analytic Core within the program. Specifically, the objectives of the PSG Core will include the following activities: 1. Acquisition and maintenance of PSG equipment and supplies 2. Training of technical research staff at the BWH Center for Clinical Investigation (CCI) in equipment use and instrumentation of research subjects for PSG 3. Assisting in PSG quality assurance at the CCI, and providing technical advice to staff and investigators 4. Archival of digitized PSG data 5. Vigilance state scoring of PSG recordings, and scoring of slow eye movements as a measure of attention failures in wake recordings 6. Quantitative analysis of the sleep EEG with Fast Fourier Transform-routine based spectral analysis in order to obtain measures of homeostatic sleep pressure and circadian sleep drive.

Public Health Relevance

The Polysomnography Core will enable and coordinate the utilization of specialized personnel, facilities, and technology across Projects 1 and 2, and will therefore be central to the success of the overall PPG. The Core will at the same time ensure standardized qualify control criteria for the acquisition, analysis and interpretation of the polysomnography data of the human research projects.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009975-17
Application #
8707294
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
17
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Leise, Tanya L; Goldberg, Ariella; Michael, John et al. (2018) Recurring circadian disruption alters circadian clock sensitivity to resetting. Eur J Neurosci :
Zitting, Kirsi-Marja; M√ľnch, Mirjam Y; Cain, Sean W et al. (2018) Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults. Sci Rep 8:11052
McHill, Andrew W; Hull, Joseph T; McMullan, Ciaran J et al. (2018) Chronic Insufficient Sleep Has a Limited Impact on Circadian Rhythmicity of Subjective Hunger and Awakening Fasted Metabolic Hormones. Front Endocrinol (Lausanne) 9:319
Li, Peng; Yu, Lei; Lim, Andrew S P et al. (2018) Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement 14:1114-1125
Todd, William D; Fenselau, Henning; Wang, Joshua L et al. (2018) A hypothalamic circuit for the circadian control of aggression. Nat Neurosci 21:717-724
Naganuma, Fumito; Bandaru, Sathyajit S; Absi, Gianna et al. (2018) Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy. Neurobiol Dis 120:12-20
Asgari-Targhi, Ameneh; Klerman, Elizabeth B (2018) Mathematical modeling of circadian rhythms. Wiley Interdiscip Rev Syst Biol Med :e1439
Kroeger, Daniel; Absi, Gianna; Gagliardi, Celia et al. (2018) Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice. Nat Commun 9:4129
Gottlieb, Daniel J; Ellenbogen, Jeffrey M; Bianchi, Matt T et al. (2018) Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study. BMC Med 16:44
Biello, Stephany M; Bonsall, David R; Atkinson, Lynsey A et al. (2018) Alterations in glutamatergic signaling contribute to the decline of circadian photoentrainment in aged mice. Neurobiol Aging 66:75-84

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