instructions): Chronic sleep disturbance is reported by nearly 50% of older adults. The high prevalence of insomnia in older adults is likely due to an interaction of age-related changes in sleep and circadian regulation, chronic illnesses and late life stressors. Recent evidence suggests that poor health contributes to poor sleep, but poor sleep can also increase the risk for poor health. Evidence from our group shows that sleep loss may promote the development or increase the severity of age-related cardio-metabolic disease. While many studies have confirmed the link between short sleep duration and cardio-metabolic disease, emerging evidence supports a relationship between insomnia symptoms and risk for cardiovascular disease. However, little is known of the impact of insomnia or its specific sleep characteristics on cardio-metabolic health in older adults. In the present study, we propose to examine in detail the relationship between sleep characteristics with cardio-metabolic risk factors in older adults with chronic insomnia. A total of 120 older adults with chronic insomnia and controls will be recruited from the Chicago Heart Association Detection Project in Industry cohort. This collaboration represents a unique and cost efficient opportunity to study the relationship between insomnia and cardio-metabolic risk factors in a large group of community based older adults ages 65-80 years of age. The overall aim of this project is to define the sleep, circadian and cardio- metabolic phenotypes of common age-related insomnia subtypes. Objective and self reported measures of nocturnal sleep, daytime sleepiness, circadian rhythm, metabolism, inflammation, and autonomic function will be assessed in older adults with chronic insomnia and compared to age, gender, race and BMI matched controls without insomnia.
The specific aims are: 1) Assess whether levels of cardio-metabolic risk factors are higher in older adults with chronic insomnia than in their counterparts without insomnia;2) Determine the role of each of the major sleep characteristics: total sleep time, sleep efficiency, latency to persistent sleep, sleep fragmentation, minutes of slow wave sleep, minutes of REM sleep, slow wave activity and high frequency activity, and daytime sleepiness on cardio-metabolic function in older adults with and without chronic insomnia;and 3) Determine the contribution of circadian phase and amplitude to the relationship between insomnia and cardio-metabolic disease risk factors. The results of the proposed study will greatly improve our understanding of the impact of insomnia and the role of specific sleep and wake characteristics on cardio-metabolic disease risk markers and daytime function in older adults.

Public Health Relevance

The proposed study has important implications for public health. If chronic insomnia in older adults is associated with elevated cardio-metabolic risk factors, it would strongly underscore the importance of identifying and treating insomnia in older adults. Furthermore, these results can provide the basis for personalized approaches to the treatment of insomnia as well as the prevention of common age associated co-morbid medical and psychiatric conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG011412-16
Application #
8376103
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
16
Fiscal Year
2012
Total Cost
$248,432
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Santostasi, Giovanni; Malkani, Roneil; Riedner, Brady et al. (2016) Phase-locked loop for precisely timed acoustic stimulation during sleep. J Neurosci Methods 259:101-14
Peek, Clara Bien; Levine, Daniel C; Cedernaes, Jonathan et al. (2016) Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Cell Metab :
Broussard, Josiane L; Kilkus, Jennifer M; Delebecque, Fanny et al. (2016) Elevated ghrelin predicts food intake during experimental sleep restriction. Obesity (Silver Spring) 24:132-8
Grimaldi, Daniela; Carter, Jason R; Van Cauter, Eve et al. (2016) Adverse Impact of Sleep Restriction and Circadian Misalignment on Autonomic Function in Healthy Young Adults. Hypertension 68:243-50
Broussard, Josiane L; Wroblewski, Kristen; Kilkus, Jennifer M et al. (2016) Two Nights of Recovery Sleep Reverses the Effects of Short-term Sleep Restriction on Diabetes Risk. Diabetes Care 39:e40-1
Mokhlesi, Babak; Grimaldi, Daniela; Beccuti, Guglielmo et al. (2016) Effect of One Week of 8-Hour Nightly Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea on Glycemic Control in Type 2 Diabetes: A Proof-of-Concept Study. Am J Respir Crit Care Med 194:516-9
Broussard, Josiane L; Van Cauter, Eve (2016) Disturbances of sleep and circadian rhythms: novel risk factors for obesity. Curr Opin Endocrinol Diabetes Obes 23:353-9
Perelis, M; Ramsey, K M; Bass, J (2015) The molecular clock as a metabolic rheostat. Diabetes Obes Metab 17 Suppl 1:99-105
Perelis, Mark; Marcheva, Biliana; Ramsey, Kathryn Moynihan et al. (2015) Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science 350:aac4250
Westerberg, Carmen E; Florczak, Susan M; Weintraub, Sandra et al. (2015) Memory improvement via slow-oscillatory stimulation during sleep in older adults. Neurobiol Aging 36:2577-86

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