The central hypothesis of Project 2, Energy Balance and Metabolism, is that dietary restriction (DR)? increases longevity through changes in energy and substrate metabolism. DR is the only known? environmental intervention that consistently increases life span. Because there is a striking relationship? between the level of caloric restriction and the magnitude of life extension in rodents, the study of energy? metabolism is a fundamental pursuit for probing the actions of DR in primates. Accordingly, we propose to? continue our pursuits in this area and have identified the following specific aims. These are to characterize? the independent and interactive effects of age and DR on:? 1. Body composition to the finest level resolvable;? 2. Multiple facets of substrate metabolism, including energy expenditure and glucose homeostasis.? effects of body composition on these outcomes will also be evaluated;? 3. The bioactivity of adipose tissue.? To date, we have documented significant reductions in chronic disease risk factors including decreased? obesity, maintenance of fat-free mass, improved insulin sensitivity, and absence of type 2 diabetes.? During the coming five years, we will utilize the PPG animals to test the general hypotheses that DR will? increase health span and, eventually life span, as displayed by reduced fat mass and metabolic rate, and? maintenance of fat-free mass, skeletal muscle mass, and insulin sensitivity. A linking hypothesis is that the? effects of DR will be mediated through changes in adipose tissue signals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG011915-12
Application #
7549113
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2007-02-01
Budget End
2008-01-31
Support Year
12
Fiscal Year
2007
Total Cost
$128,503
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Mattison, Julie A; Colman, Ricki J; Beasley, T Mark et al. (2017) Caloric restriction improves health and survival of rhesus monkeys. Nat Commun 8:14063
Polewski, Michael A; Burhans, Maggie S; Zhao, Minghui et al. (2015) Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys. J Lipid Res 56:1461-70
Fowler, Cynthia G; Chiasson, Kirstin Beach; Colman, Ricki J et al. (2015) Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys. Hear Res 328:78-86
Barger, Jamie L; Anderson, Rozalyn M; Newton, Michael A et al. (2015) A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. PLoS One 10:e0120738
Colman, Ricki J; Beasley, T Mark; Kemnitz, Joseph W et al. (2014) Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun 5:3557
Sridharan, Aadhavi; Bendlin, Barbara B; Gallagher, Catherine L et al. (2014) Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: a fiber tractography study. Neurosci Lett 569:38-42
Pugh, Thomas D; Conklin, Matthew W; Evans, Trent D et al. (2013) A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys. Aging Cell 12:672-81
Willette, A A; Coe, C L; Birdsill, A C et al. (2013) Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age (Dordr) 35:2215-27
Csiszar, Anna; Sosnowska, Danuta; Tucsek, Zsuzsanna et al. (2013) Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. J Gerontol A Biol Sci Med Sci 68:235-49

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