This Program Project asks: Can dietary restriction (DR), long known to retard aging and diseases in rodents, do so in nonhuman primates? Our hypothesis is that DR will similarly retard aging in a primate species, as reflected by attenuated rates of change of most biological indicators of aging and increased health span and life span. Two overall Specific Aims continue to be addressed. Sp.
Aim 1 is to contribute to the development of the rhesus monkey as a model for the study of aging. Our longitudinal study should lead to an improved understanding of biological aging in this model. Ongoing study of conventionally-fed animals from our large aging colony will be continued as will investigation of three Groups of DR and Control rhesus monkeys, all of which were young adults (-10 yrs. old) when entering the study. Group 1 (n=15/group, males) began in 1989 with R01 funding. In 1994, with PPG support, we added 46 animals to increase statistical power for the key outcome measures on health span and life span. These were Group 2 (n = 15/group, females) and Group 3 (n = 8/group, males). These three Groups allow us to address Sp.
Aim 2 : to determine the influence of DR on the rate of aging in a primate species.

Public Health Relevance

The proposed work which utilizes the outstanding Primate Center and this precious animal resource will extend our 16-year-long study of aging and DR, an issue at the heart of gerontology and of widespread interest to the general populace.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1 (O1))
Program Officer
Finkelstein, David B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Maegawa, Shinji; Lu, Yue; Tahara, Tomomitsu et al. (2017) Caloric restriction delays age-related methylation drift. Nat Commun 8:539
Mattison, Julie A; Colman, Ricki J; Beasley, T Mark et al. (2017) Caloric restriction improves health and survival of rhesus monkeys. Nat Commun 8:14063
Polewski, Michael A; Burhans, Maggie S; Zhao, Minghui et al. (2015) Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys. J Lipid Res 56:1461-70
Fowler, Cynthia G; Chiasson, Kirstin Beach; Colman, Ricki J et al. (2015) Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys. Hear Res 328:78-86
Barger, Jamie L; Anderson, Rozalyn M; Newton, Michael A et al. (2015) A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. PLoS One 10:e0120738
Colman, Ricki J; Beasley, T Mark; Kemnitz, Joseph W et al. (2014) Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun 5:3557
Sridharan, Aadhavi; Bendlin, Barbara B; Gallagher, Catherine L et al. (2014) Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: a fiber tractography study. Neurosci Lett 569:38-42
Pugh, Thomas D; Conklin, Matthew W; Evans, Trent D et al. (2013) A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys. Aging Cell 12:672-81
Willette, A A; Coe, C L; Birdsill, A C et al. (2013) Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age (Dordr) 35:2215-27
Csiszar, Anna; Sosnowska, Danuta; Tucsek, Zsuzsanna et al. (2013) Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. J Gerontol A Biol Sci Med Sci 68:235-49

Showing the most recent 10 out of 120 publications