The goals of Core B are (/) to obtain, preserve, examine, diagnose, and disseminate human brain tissue from autopsies of patients with Alzheimer's disease (AD) and patients with Lewy body dementia (LBD) as well as appropriate controls;(if) process, embed, and section animal tissues and prepare tissue cultures generated by the projects for morphologic, immunohistochemical, and in situ hybridization characterization and investigation. Continued achievementof these goals will enhance and facilitate achievement of the aims of the Projects in this Program Project. In these ways, this Core will facilitate investigations of glial-neuronal relationships underlying early pathogenic events in the development of the neuropathologic features of AD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG012411-16
Application #
8446385
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
16
Fiscal Year
2013
Total Cost
$183,346
Indirect Cost
$52,099
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Wang, Wei; Bodles-Brakhop, Angela M; Barger, Steven W (2016) A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid β -Peptide from the Brain. Curr Alzheimer Res 13:615-20
Mao, Xianrong; Phanavanh, Bounleut; Hamdan, Hamdan et al. (2016) NFκB-inducing kinase inhibits NFκB activity specifically in neurons of the CNS. J Neurochem 137:154-63
Zawada, W Michael; Mrak, Robert E; Biedermann, JoAnn et al. (2015) Loss of angiotensin II receptor expression in dopamine neurons in Parkinson's disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation. Acta Neuropathol Commun 3:9
Aboud, Orwa; Aboud, Talal; Janjua, M Burhan et al. (2015) Image-Guided Spinal Navigation for C1-C2 Instrumentation: Part I. Contemp Neurosurg 37:1-6
Deng, Juan; Habib, Ahsan; Obregon, Demian F et al. (2015) Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3β signaling pathway. J Neurochem 135:630-7
Pey, Peixuan; Pearce, Ronald K B; Kalaitzakis, Michail E et al. (2014) Phenotypic profile of alternative activation marker CD163 is different in Alzheimer's and Parkinson's disease. Acta Neuropathol Commun 2:21
Aboud, Orwa; Griffin W, Sue T (2014) Silver Staining of Alzheimer's Disease. J Neurol Disord 2:
Kuang, Xiu-Li; Liu, Fang; Chen, Huifang et al. (2014) Reductions of the components of the calreticulin/calnexin quality-control system by proteasome inhibitors and their relevance in a rodent model of Parkinson's disease. J Neurosci Res 92:1319-29
Zhang, Hanying; Okamoto, Miyako; Panzhinskiy, Evgeniy et al. (2014) PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells. Am J Physiol Cell Physiol 306:C648-58
Barger, Steven W (2013) Apolipoprotein E acts at pre-synaptic sites...among others. J Neurochem 124:1-3

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