The overarching goal of this competitive renewal application is to examine the pleiotropic effects of arteriosclerosis (AS), on brain structure and function, either alone or in combination with Alzheimer disease (AD). We propose a prospective, longitudinal study of a convenience sample (231 current + 276 new = 507 subjects), selected using the Framingham cardiovascular risk profile (FCRP) to ensure representation of subjects ranging from little to severe arteriosclerosis (AS). The PPG includes 4 Cores (Administrative, Clinical, Imaging, and Pathology) and 4 Projects. Project 1 (Reed &Jagust) will use amyloid imaging (Pittsburgh Imaging B [PIB] compound) to identify in vivo a cohort of subjects representing the full spectrum of AS, with minimal AD pathology. Project 2 (Weiner, DeCarli, and Singh) will determine the extent to which arteriosclerosis (AS) is associated with changes of brain perfusion and volume and integrity of gray matter (GM) and white matter (WM) and the extent to which these associations relate to AD- vs. CVD-pathology. .Project 6 (Zarow &Vinters) seeks to improve the clinical diagnosis of hippocampal sclerosis and to clarify its pathogenesis. Project 7 (Chui &Mungas) will test the overarching hypothesis using data obtained in the Clinical, Imaging, and Pathology Cores.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG012435-18
Application #
8286255
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J2))
Program Officer
Hsiao, John
Project Start
1997-09-15
Project End
2014-05-31
Budget Start
2012-06-15
Budget End
2014-05-31
Support Year
18
Fiscal Year
2012
Total Cost
$1,869,094
Indirect Cost
$220,353
Name
University of Southern California
Department
Neurology
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Reed, Bruce; Villeneuve, Sylvia; Mack, Wendy et al. (2014) Associations between serum cholesterol levels and cerebral amyloidosis. JAMA Neurol 71:195-200
Villeneuve, Sylvia; Reed, Bruce R; Wirth, Miranka et al. (2014) Cortical thickness mediates the effect of ?-amyloid on episodic memory. Neurology 82:761-7
Lee, Jun-Young; Park, Soowon; Mackin, Scott et al. (2014) Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression. PLoS One 9:e87747
Kolar, Grant R; Kothari, Parul H; Khanlou, Negar et al. (2014) Neuropathology and genetics of cerebroretinal vasculopathies. Brain Pathol 24:510-8
Sanchez-Juan, Pascual; Ghosh, Pia M; Hagen, Jayne et al. (2014) Practical utility of amyloid and FDG-PET in an academic dementia center. Neurology 82:230-8
Tsao, Sinchai; Gajawelli, Niharika; Hwang, Darryl Hwa et al. (2014) Mapping of ApoE4 Related White Matter Damage using Diffusion MRI. Proc SPIE Int Soc Opt Eng 9039:90390H
Tsao, Sinchai; Ma, Samantha J; Michels, Peter A et al. (2014) The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR. Proc SPIE Int Soc Opt Eng 9039:90390I
Lyness, Scott A; Lee, Ae Young; Zarow, Chris et al. (2014) 10-minute delayed recall from the modified mini-mental state test predicts Alzheimer's disease pathology. J Alzheimers Dis 39:575-82
Marchant, Natalie L; Reed, Bruce R; Sanossian, Nerses et al. (2013) The aging brain and cognition: contribution of vascular injury and aýý to mild cognitive dysfunction. JAMA Neurol 70:488-95
Zhang, Yu; Schuff, Norbert; Camacho, Monica et al. (2013) MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements. PLoS One 8:e66367

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