The Program Project on """"""""Reactive Oxygen Species and Aging"""""""" will include three Projects and two scientific Cores, all located at the University of Kansas. The Principal Investigator will continue in his function as the Leader of Core A, the Administrative Core. The goals of Core A are: a) Provide administrative leadership and coordination of the research effort in the study of aging, b) Provide appropriate administrative support, c) Offer expert external review and consultation, d) Organize scientific exchanges in the form of symposia, e) Promote scientific interactions and create a cohesive research environment. And, f) Obtain support from the Institution as needed. The overarching goal is that the whole of this Program Project is greater than the sum of the individual Projects and Cores. Meeting these goals defines the purpose of the Administrative Core, which is: to provide for the overall direction and management of the Program;to make sure that the Project and Core staff remain cohesive and focused on common scientific goals;to provide opportunities for reviews, consultations, and exchanges with the scientific community;and, to represent the scientific interests of the investigators to the University and secure support for laboratory facilities as needed. The progress that Core A has made in providing for the successful, collaborative and forward-looking scientific efforts of the investigators in the Projects and Cores is attested by the productivity of the investigators, their commitment to the goals of the Project, their collaborations, and their efforts to introduce new technologies and new resources.
The aims of Core A are to: 1) Provide administrative leadership and coordination of the overall research effort with the goal of producing high quality science in the study of aging;2) Provide appropriate administrative, accounting and other management support;3) Offer expert external review and consultation for optimal progress of the research;4) Organize bi-annual symposia on """"""""Molecular Mechanisms of Aging, Oxidative Stress and Ca2+ Regulation"""""""";5) Promote scientific interactions, exchange information and share data/resources;and 6) Obtain support from the Institution as needed for the expansion of the research capabilities of the Project.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG012993-14
Application #
8234020
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
14
Fiscal Year
2011
Total Cost
$89,118
Indirect Cost
Name
University of Kansas Lawrence
Department
Type
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Hewarathna, Asha; Dremina, Elena; Schöneich, Christian (2017) Inhibition and conformational change of SERCA3b induced by Bcl-2. Biochim Biophys Acta 1865:121-131
Schöneich, Christian (2016) Thiyl radicals and induction of protein degradation. Free Radic Res 50:143-9
Poole, Leslie B; Schöneich, Christian (2015) Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways. Free Radic Biol Med 80:145-7
Nauser, Thomas; Koppenol, Willem H; Schöneich, Christian (2015) Protein thiyl radical reactions and product formation: a kinetic simulation. Free Radic Biol Med 80:158-63
Badawi, Yomna; Pal, Ranu; Hui, Dongwei et al. (2015) Ischemic tolerance in an in vivo model of glutamate preconditioning. J Neurosci Res 93:623-32
Choi, In-Young; Lee, Phil; Wang, Wen-Tung et al. (2014) Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice. Neurochem Res 39:446-55
Wang, Xinkun; Patel, Nilam D; Hui, Dongwei et al. (2014) Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice. BMC Neurosci 15:37
Schöneich, Christian; Dremina, Elena; Galeva, Nadezhda et al. (2014) Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes. Apoptosis 19:42-57
Jiang, Lei; Bechtel, Misty D; Bean, Jennifer L et al. (2014) Effects of gangliosides on the activity of the plasma membrane Ca2+-ATPase. Biochim Biophys Acta 1838:1255-65
Wang, Shu-Lin; Sun, Liuchao; Fang, Jianwen (2014) Molecular cancer classification using a meta-sample-based regularized robust coding method. BMC Bioinformatics 15 Suppl 15:S2

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