The main functions of the Administrative Core are to: a) facilitate distribution of research materials and resources to the various investigators;b) facilitate communication between investigators, cores the advisory committees, affiliated institutions and the funding agency;c) evaluate the quality of ongoing research as well as programs to be considered for future expansion;d) cut brain tissue specimens and harvest frozen specimens for distribution, in a blinded fashion for investigators;d) interact with Core B and e) maintain a web page for the PPG. Core A functions will be accomplished with the help of three different committees: 1) the Internal Advisory group consisting of project and core leaders. It will meet on a monthly basis to discuss research projects, protocols, results and any problems that might arise in this collaborative effort. The External Advisory Committee which consists of scientists with expertise in various disciplines represented in this application will meet with Internal Advisory Committee every other a year. In the off years there will be video conferences. It will review progress and advise on the overall quality of the work. Meeting will be chaired by the Core leader. Dr. Mufson. These meetings will provide a forum for discussing new ideas and a mechanism for expanding the program with worthy projects in the future. The Administrative Core will be led by the Principal Investigator and Co-PL of the Core.

Public Health Relevance

A centralized Administrative Core is a necessity for the daily function of the entire program project since it the PPG brings together investigators from three NIA funded Alzheimer's disease center. The core coordinates budgetary and organization issues as well as transfers and tracks tissue specimens provided for each subproject.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG014449-16
Application #
8789053
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (02))
Project Start
2013-12-01
Project End
2019-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
16
Fiscal Year
2014
Total Cost
$322,275
Indirect Cost
$111,638
Name
Rush University Medical Center
Department
Type
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612
Perez, Sylvia E; He, Bin; Nadeem, Muhammad et al. (2015) Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biol Psychiatry 77:693-703
Alldred, Melissa J; Lee, Sang Han; Petkova, Eva et al. (2015) Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. J Comp Neurol 523:61-74
Alldred, Melissa J; Lee, Sang Han; Petkova, Eva et al. (2015) Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain Struct Funct 220:2983-96
Counts, Scott E; Alldred, Melissa J; Che, Shaoli et al. (2014) Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment. Neuropharmacology 79:172-9
Counts, Scott E; Ray, Balmiki; Mufson, Elliott J et al. (2014) Intravenous immunoglobulin (IVIG) treatment exerts antioxidant and neuropreservatory effects in preclinical models of Alzheimer's disease. J Clin Immunol 34 Suppl 1:S80-5
Ash, Jessica A; Velazquez, Ramon; Kelley, Christy M et al. (2014) Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiol Dis 70:32-42
Hales, Chadwick M; Dammer, Eric B; Diner, Ian et al. (2014) Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease. Brain Pathol 24:344-51
Yan, Jian; Ginsberg, Stephen D; Powers, Brian et al. (2014) Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice. FASEB J 28:4312-23
Hales, Chadwick M; Seyfried, Nicholas T; Dammer, Eric B et al. (2014) U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21. Mol Neurodegener 9:15
James, Bryan D; Leurgans, Sue E; Hebert, Liesi E et al. (2014) Contribution of Alzheimer disease to mortality in the United States. Neurology 82:1045-50

Showing the most recent 10 out of 176 publications