The Administrative and Educational Core plays the key role of managing and integrating all the activities of our highly interactive research group.
The aims of Core A (below) are designed to effectively administer the scientific planning, data and reagent sharing, education, consultation and administrative functions of our program, and they reflect the commitment of the 5 principal investigators to their continued scientific development as well as that of the program as a whole. Expenses for all non-experimental parts of this Program are included in the Core A budget.
The Aims of Core A are: 1) To enhance the scientific exchange, collaboration and communication among all the co-investigators and their respective scientific personnel across the 6 labs of the program (4 at MGH and 2 at BWH), including inter-institutional personnel and reagent exchanges, assisting with joint publications, regular exchange of all publications emanating from the grant, and internal sharing of mentoring responsibilities. 2) To contribute to the continuing education of the program's members and the Boston scientific community at large about new developments in basic and applied biology related to neurodegeneration, via our highly successful seminar series. 3) To efficiently manage the program's business activities, including regular income/expense reports, preparation of progress reports each year, organization of this competitive renewal application, and communications with the NIA. The Administrative Coordinator, under the guidance of the Program Director, functions as the point person for all the business and administrative tasks related to the above 3 aims as they arise from the following specific responsibilities. These are: the coordination of meetings of the Working Group and the Scientific Advisory Board (SAB) and the preparation of meeting materials and any travel-related issues for SAB members;organizing, scheduling and publicizing our annual seminar series and handling all speaker-related issues, including scheduling meetings with program scientists, coordinating travel needs, processing reimbursements, etc.;assisting with distribution of publications arising from the program among our personnel as well as dealing with shipments or licensing issues related to the resources and reagents generated by the program;managing all processes related to the timely submission of reports, renewal applications or any other communications with the NIA. In short, the Administrative Coordinator ensures the smooth and timely functioning of all non-scientific aspects of the program project on a daily basis and is an indispensible part of the Core.

National Institute of Health (NIH)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1)
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Brigham and Women's Hospital
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Holmes, Oliver; Paturi, Swetha; Wolfe, Michael S et al. (2014) Functional analysis and purification of a Pen-2 fusion protein for ?-secretase structural studies. J Neurochem 131:94-100
McFarland, Karen N; Huizenga, Megan N; Darnell, Shayna B et al. (2014) MeCP2: a novel Huntingtin interactor. Hum Mol Genet 23:1036-44
Li, Yi; Lu, Stephen Hsueh-Jeng; Tsai, Ching-Ju et al. (2014) Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure 22:125-35
Choi, Se Hoon; Kim, Young Hye; Hebisch, Matthias et al. (2014) A three-dimensional human neural cell culture model of Alzheimer's disease. Nature 515:274-8
Bolduc, David M; Wolfe, Michael S (2014) Structure of nicastrin unveils secrets of ?-secretase. Proc Natl Acad Sci U S A 111:14643-4
Winslow, Ashley R; Moussaud, Simon; Zhu, Liya et al. (2014) Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease. Brain 137:1958-70
Holmes, Oliver; Paturi, Swetha; Selkoe, Dennis J et al. (2014) Pen-2 is essential for ?-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry 53:4393-406
Kim, Doo Yeon; Wertz, Mary H; Gautam, Vivek et al. (2014) The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells. Neurodegener Dis 13:64-8
Wahlster, Lara; Arimon, Muriel; Nasser-Ghodsi, Navine et al. (2013) Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Acta Neuropathol 125:187-99
Li, Xuejing; Uemura, Kengo; Hashimoto, Tadafumi et al. (2013) Neuronal activity and secreted amyloid ? lead to altered amyloid ? precursor protein and presenilin 1 interactions. Neurobiol Dis 50:127-34

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