The goal of the Administrative and Data Management Core (Core B) of this Program Project Grant (PPG) is to maximize the productivity of all participants by the coordination and integration of scientific, fiscal and administrative activities, and provide a coordinated mechanism for data analysis and management. Core B is directed by the overall PI of the PPG, will continue to provide support to all four Projects in the PPG, as well as Core A, The Nonhuman Primate Core, at the California National Primate Research Center (CNPRC). The specific responsibilities of Core B are as follows: 1) To provide leadership and an administrative framework to facilitate interactions and communications among all the participating Project and Core Leaders (PLs) and across the multiple sites by creating a centralized mechanism for the coordination and management of research activities. 2) To centralize the administration of fiscal, clerical and personnel matters, and provide an administrative liaison between the Grants and Contracts Office of the Mount Sinai School of Medicine and other sites where research is conducted. 3. To organize all travel for perfusions of non-human primates at the CNPRC and assure that tissues are properly distributed. To assist Dr. Gore as needed in organizing and coordinating all distribution of rat tissues, which originate from Project 2 at The University of Texas at Austin. 4) To provide assistance with statistical analysis to all individual Projects, and in particular, provide analysis for comparisons of findings across Projects. Also, Core B will provide a consolidated mechanism for data organization and storage. 5) To ensure the smooth function and integration of PPG components by organizing frequent informal meetings, video conferences, and teleconferences with other PLs as well as formal meetings with the External Advisory Committee. 6) To facilitate the use of resources generated through this program by other investigators.

Public Health Relevance

This core fosters the integration and collaboration required for the Program Project participants to reach their goal: to understand the aging brain and female reproductive senescence and develop hormone treatments applicable to women that will maximize neurological health.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-9)
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Icahn School of Medicine at Mount Sinai
New York
United States
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McEwen, Bruce S; Milner, Teresa A (2017) Understanding the broad influence of sex hormones and sex differences in the brain. J Neurosci Res 95:24-39
Nutsch, Victoria L; Will, Ryan G; Tobiansky, Daniel J et al. (2017) Age-related changes in sexual function and steroid-hormone receptors in the medial preoptic area of male rats. Horm Behav 96:4-12
Nutsch, Victoria L; Bell, Margaret R; Will, Ryan G et al. (2017) Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats. Mol Cell Endocrinol 442:153-164
Marques-Lopes, Jose; Tesfaye, Ephrath; Israilov, Sigal et al. (2017) Redistribution of NMDA Receptors in Estrogen-Receptor-?-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure. Neuroendocrinology 104:239-256
Garcia, Alexandra N; Bezner, Kelsey; Depena, Christina et al. (2017) The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats. Horm Behav 87:145-154
Almey, Anne; Milner, Teresa A; Brake, Wayne G (2016) Estrogen receptor ? and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum. Neurosci Lett 622:118-23
Mazid, Sanoara; Hall, Baila S; Odell, Shannon C et al. (2016) Sex differences in subcellular distribution of delta opioid receptors in the rat hippocampus in response to acute and chronic stress. Neurobiol Stress 5:37-53
Naugle, Michelle M; Lozano, Sateria A; Guarraci, Fay A et al. (2016) Age and Long-Term Hormone Treatment Effects on the Ultrastructural Morphology of the Median Eminence of Female Rhesus Macaques. Neuroendocrinology 103:650-64
Garcia, Alexandra N; Depena, Christina K; Yin, Weiling et al. (2016) Testing the critical window of estradiol replacement on gene expression of vasopressin, oxytocin, and their receptors, in the hypothalamus of aging female rats. Mol Cell Endocrinol 419:102-12
Marques-Lopes, Jose; Lynch, Mary-Katherine; Van Kempen, Tracey A et al. (2015) Female protection from slow-pressor effects of angiotensin II involves prevention of ROS production independent of NMDA receptor trafficking in hypothalamic neurons expressing angiotensin 1A receptors. Synapse 69:148-65

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